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Proteintech
Hexokinase 2 Monoclonal Antibody (2A11C3), CoraLite® 594
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Product Details
CL594-66974
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2A11C3
Immunogen
Hexokinase 2 fusion protein Ag16895
Conjugate
Excitation/Emission Max
593/614 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: HGTGDELFDH IVQCIADFLE YMGMKGVSLP LGFTFSFPCQ QNSLDESILL KWTKGFKASG CEGEDVVTLL KEAIHRREEF DLDVVAVVND TVGTMMTCGF EDPHCEVGLI VGTGSNACYM EEMRNVELVE GEEGRMCVNM EWGAFGDNGC LDDFRTEFDV AVDELSLNPG KQRFEKMISG MYLGEIVRNI LIDFTKRGLL FRGRISERLK TRGIFETKFL SQIESDCLAL LQVRAILQHL GLESTCDDSI IVKEVCTVVA RRAAQLCGAG MAAVVDRIRE NRGLDALKVT VGVDGTLYKL HPHFAKVMHE TVKDLAPKCD VSFLQSEDGS GKGAALITAV ACRIREAGQR
Target Information
In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase activity is involved in the first step in several metabolic pathways including phosphorylation of glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Hexokinase is an allosteric enzyme inhibited by its product GLC-6-P. Hexokinase 2 is the predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686M1669; Hexokinase; Hexokinase type II; Hexokinase-2; hexokinase-2 muscle; hexokinase-2, muscle; Hexokinase-B; HK II; Muscle form hexokinase; OTTHUMP00000202738; unnamed protein product
Gene Aliases: AI642394; HK2; HKII; HXK2
UniProt ID: (Human) P52789, (Mouse) O08528, (Rat) P27881
Entrez Gene ID: (Human) 3099, (Mouse) 15277, (Rat) 25059
response to hypoxia
cellular glucose homeostasis
response to ischemia
carbohydrate metabolic process
fructose 6-phosphate metabolic process
glucose metabolic process
glycolytic process
lactation
apoptotic mitochondrial changes
hexose metabolic process
organophosphate metabolic process
negative regulation of mitochondrial membrane permeability
positive regulation of angiogenesis
regulation of glucose import
carbohydrate phosphorylation
glucose 6-phosphate metabolic process
canonical glycolysis
establishment of protein localization to mitochondrion
maintenance of protein location in mitochondrion
carbohydrate derivative metabolic process
positive regulation of type 2 mitophagy
cellular response to leukemia inhibitory factor
negative regulation of reactive oxygen species metabolic process
metabolic process
phosphorylation
glucose catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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