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Proteintech
INTS3 Monoclonal Antibody (2G11B7), CoraLite® 594
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Product Details
CL594-67060
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
2G11B7
Immunogen
Recombinant Protein
Conjugate
Excitation/Emission Max
593/614 nm
Form
Liquid
Concentration
2 mg/mL
Amount
200 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Target Information
Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.; FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Int3; Integrator complex subunit 3; Sensor of single-strand DNA complex subunit A; sensor of ssDNA subunit A; SOSS complex subunit A; SOSS-A; unnamed protein product
Gene Aliases: C1orf193; C1orf60; C77668; INT3; INTS3; RGD1304593; SOSS-A; SOSSA
UniProt ID: (Human) Q68E01, (Mouse) Q7TPD0
Entrez Gene ID: (Human) 65123, (Mouse) 229543, (Rat) 361988
DNA repair
cellular response to DNA damage stimulus
mitotic cell cycle checkpoint
response to ionizing radiation
snRNA processing
double-strand break repair via homologous recombination
regulation of transcription elongation from RNA polymerase II promoter
mitotic G2/M transition checkpoint
RNA polymerase II transcription initiation surveillance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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