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ADRBK1 Monoclonal Antibody (2F7A5), CoraLite® 594
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
CL594-67067
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2F7A5
Immunogen
ADRBK1 fusion protein Ag5071
Conjugate
CoraLite® 594
CoraLite® 594
CoraLite® 594
Excitation/Emission Max
593/614 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: PFRQHKTKDK HEIDRMTLTM AVELPDSFSP ELRSLLEGLL QRDVNRRLGC LGRGAQEVKE SPFFRSLDWQ MVFLQKYPPP LIPPRGEVNA ADAFDIGSFD EEDTKGIKLL DSDQELYRNF PLTISERWQQ EVAETVFDTI NAETDRLEAR KKAKNKQLGH EEDYALGKDC IMHGYMSKMG NPFLTQWQRR YFYLFPNRLE WRGEGEAPQS LLTMEEIQSV EETQIKERKC LLLKIRGGKQ FILQCDSDPE LVQWKKELRD AYREAQQLVQ RVPKMKNKPR SPVVELSKVP LVQRGSANGL
Target Information
ADRBK1 (GRK2) is a serine/threonine kinase. Many of the G protein-coupled receptors are known to be phosphorylated by G protein-dependent receptor kinases (GRKs). G protein-coupled receptor kinases (GRKs) are important regulators of G protein-coupled receptors(GPCRs). GRK2 (83 kDa), one of six members of this family that have been identified, is ubiquitously expressed in mammals. After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs (e.g., a2-adrenergic receptor) are phosphorylated by GRKs. Internalization of the GPCRs, regulated by beta-arrestin-1, leads to activation of the Ras - Raf - ERK1&2 signaling pathway. GRK2 activity is tightly controlled by different mechanisms including phosphorylation by kinases such as PKC, Src and ERK1&2, as well as interaction with various proteins. ERK phosphorylates and thus inactivates GRK2 on serine 670 in a negative feedback mechanism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adrenergic beta receptor kinase 1; beta-ARK-1; EC 2.7.1.126; grk 2
Gene Aliases: ADRBK1; BARK1; BETA-ARK1
UniProt ID: (Human) P25098
Entrez Gene ID: (Human) 156
regulation of the force of heart contraction
desensitization of G-protein coupled receptor protein signaling pathway
negative regulation of the force of heart contraction by chemical signal
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
tachykinin receptor signaling pathway
viral genome replication
receptor internalization
positive regulation of catecholamine secretion
intraciliary retrograde transport
positive regulation of smoothened signaling pathway
negative regulation of striated muscle contraction
viral entry into host cell
cardiac muscle contraction
negative regulation of relaxation of smooth muscle
negative regulation of protein localization to ciliary membrane
positive regulation of intraciliary retrograde transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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