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RALA Monoclonal Antibody (1H9H5), CoraLite® 594
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FIGURE: 1 / 1
RALA Antibody (CL594-67093) in Flow
1x10^6 MCF-7 cells were intracellularly stained with 0.8 µg CoraLite®594 Anti-Human RALA (CL594-67093, Clone: 1H9H5) (red), or 0.8 µg CoraLite®594 Mouse IgG2a Isotype Control (C1.18.4) (CL594-65208, Clone: C1.18.4) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL594-67093
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1H9H5
Immunogen
RALA fusion protein Ag5329
Conjugate
Excitation/Emission Max
593/614 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MAANKPKGQ NSLALHKVIM VGSGGVGKSA LTLQFMYDEF VEDYEPTKAD SYRKKVVLDG EEVQIDILDT AGQEDYAAIR DNYFRSGEGF LCVFSITEME SFAATADFRE QILRVKEDEN VPFLLVGNKS DLEDKRQVSV EEAKNRAEQW NVNYVETSAK TRANVDKVFF DLMREIRARK MEDSKEKNGK KKRKSLAKRI RERCCIL
Target Information
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTP-binding protein (ral); MGC48949; RALA Ras like proto-oncogene A; Ras family small GTP binding protein RALA; ras related GTP binding protein A; RAS-like protein A; Ras-related protein Ral-A; small GTP binding protein; unnamed protein product; v-ral simian leukemia viral oncogene homolog A (ras related)
Gene Aliases: HINCONS; RAL; RALA
UniProt ID: (Human) P11233
Entrez Gene ID: (Human) 5898
neural tube closure
exocytosis
chemotaxis
signal transduction
Ras protein signal transduction
regulation of exocytosis
receptor internalization
regulation of actin cytoskeleton organization
positive regulation of epidermal growth factor receptor signaling pathway
cell division
positive regulation of filopodium assembly
membrane raft localization
establishment of protein localization to mitochondrion
positive regulation of mitochondrial fission
regulation of postsynaptic neurotransmitter receptor internalization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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