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Proteintech
PRDX6 Monoclonal Antibody (3C12D3), CoraLite® 594
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FIGURE: 1 / 1
PRDX6 Antibody (CL594-67499) in Flow
1X10^6 HeLa cells were intracellularly stained with 0.4 µg CoraLite®594 Anti-Human PRDX6 (CL594-67499, Clone:3C12D3) (red), or 0.4 µg Mouse IgG2a Isotype Control (CL594-66360-2, Clone: K11A1B2A2) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL594-67499
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
3C12D3
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
593/614 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MPGGLLLGDV APNFEANTTV GRIRFHDFLG DSWGILFSHP RDFTPVCTTE LGRAAKLAPE FAKRNVKLIA LSIDSVEDHL AWSKDINAYN CEEPTEKLPF PIIDDRNREL AILLGMLDPA EKDEKGMPVT ARVVFVFGPD KKLKLSILYP ATTGRNFDEI LRVVISLQLT AEKRVATPVD WKDGDSVMVL PTIPEEEAKK LFPKGVFTKE LPSGKKYLRY TPQP
Target Information
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1-Cys peroxiredoxin; 1-Cys PRX; 24 kDa protein; Acidic calcium-independent phospholipase A2; aiPLA2; Antioxidant protein 2; epididymis secretory sperm binding protein Li 128m; Glutathione-dependent peroxiredoxin; Liver 2D page spot 40; LPC acyltransferase 5; Lysophosphatidylcholine acyltransferase 5; MGC46173; MSP23; NKEFA; Non-selenium glutathione peroxidase; non-selenium glutathione phospholipid hydroperoxide peroxidase; NSGPx; PAG; PAGA; PAGB; Peroxiredoxin-6; Prx6; Red blood cells page spot 12
Gene Aliases: 1-Cys; 1-Cys PRX; aiPLA2; AOP2; HEL-S-128m; KIAA0106; NSGPx; p29; PHGPX; PRDX6; PRX
UniProt ID: (Human) P30041, (Pig) Q9TSX9
Entrez Gene ID: (Human) 9588, (Pig) 399538
glutathione peroxidase activity
protein binding
hydrolase activity
ubiquitin protein ligase binding
peroxiredoxin activity
cadherin binding involved in cell-cell adhesion
identical protein binding
calcium-independent phospholipase A2 activity
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
peroxidase
response to reactive oxygen species
lipid catabolic process
hydrogen peroxide catabolic process
cell redox homeostasis
oxidation-reduction process
cell-cell adhesion
cellular oxidant detoxification
response to oxidative stress
glycerophospholipid catabolic process
positive regulation of mRNA splicing, via spliceosome
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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