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TAK1 Monoclonal Antibody (1A5B2), CoraLite® 594

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TAK1 Monoclonal Antibody (1A5B2), CoraLite® 594

Product Details

CL594-67707

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1A5B2

Immunogen

TAK1 fusion protein Ag21286
View immunogen

Conjugate

CoraLite® 594 CoraLite® 594 CoraLite® 594

Excitation/Emission Max

593/614 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 0.5% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MSTASAASSS SSSSAGEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY F

Target Information

TAK1 (also known as MAP3K7), a part of the serine/threonine kinase family, is a versatile protein with many signaling functions. Originally identified as a TGF- beta-activated kinase, TAK1 interacts with TGF- beta-receptor and TRAF6 to modulate TGF- beta activation of JNK and p38. It has additional roles in activation of p38 and JNK through Wnt, BMP, and activin signaling pathways as well in response to thyroid hormone, osmotic stress, endothelin, and ephrine. Through activation of von Hippel-Lindau tumor suppressor expression, TAK1 represses PDGF-B, integrin beta1 and integrin beta5, promoting proper wound healing. TAK1 also plays an essential role in IKK activation in numerous signaling pathways including IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination. In this process, TAB2/3 binds to the C-terminal region of TAK1 and becomes polyubiquitinated, TAK1 is autophosphorylated at Thr178, Thr184, Thr187 and Ser192, and finally TAK1 phosphorylates IKK- beta. Additionally, TAK1 represses human telomerase reverse transcriptase suggesting a role in regulation of cell lifespan.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: M3K7; mitogen activated protein kinase kinase kinase 7; Mitogen-activated protein kinase kinase kinase 7; RP1-154G14.1; TAK1d; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor beta-activated kinase 1; Transforming growth factor-beta-activated kinase 1; unnamed protein product

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Gene Aliases: B430101B05; C87327; CSCF; FMD2; MAP3K7; MEKK7; TAK1; TGF1a

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UniProt ID: (Human) O43318, (Mouse) Q62073, (Rat) P0C8E4

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Entrez Gene ID: (Human) 6885, (Mouse) 26409, (Rat) 313121

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Function(s)
nucleotide binding magnesium ion binding transcription coactivator binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity MAP kinase kinase kinase activity receptor binding type II transforming growth factor beta receptor binding protein binding ATP binding MAP kinase kinase kinase kinase activity kinase activity transferase activity protein kinase binding receptor tyrosine kinase binding ubiquitin protein ligase binding histone kinase activity identical protein binding metal ion binding scaffold protein binding protein serine kinase activity protein serine/threonine kinase binding DNA-binding transcription factor binding linear polyubiquitin binding MAP kinase kinase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
Process(es)
MAPK cascade response to hypoxia stimulatory C-type lectin receptor signaling pathway positive regulation of T cell cytokine production cytoplasmic pattern recognition receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway chromatin remodeling apoptotic process inflammatory response immune response signal transduction transforming growth factor beta receptor signaling pathway I-kappaB kinase/NF-kappaB signaling I-kappaB phosphorylation JNK cascade positive regulation of metabolic process positive regulation of autophagy negative regulation of gene expression positive regulation of macroautophagy signal transduction involved in regulation of gene expression SCF-dependent proteasomal ubiquitin-dependent protein catabolic process positive regulation of type I interferon production protein exit from endoplasmic reticulum positive regulation of interleukin-2 production toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway TRIF-dependent toll-like receptor signaling pathway nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway NIK/NF-kappaB signaling p38MAPK cascade Fc-epsilon receptor signaling pathway interleukin-33-mediated signaling pathway interleukin-17A-mediated signaling pathway defense response to bacterium signal transduction in response to DNA damage positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling anoikis positive regulation of MAPK cascade positive regulation of JUN kinase activity positive regulation of cell cycle positive regulation of cell size T cell receptor signaling pathway stress-activated MAPK cascade interleukin-1-mediated signaling pathway cellular response to tumor necrosis factor cellular response to hypoxia cellular response to transforming growth factor beta stimulus cGAS/STING signaling pathway positive regulation of cGAS/STING signaling pathway negative regulation of cytokine production involved in inflammatory response positive regulation of NIK/NF-kappaB signaling cellular response to angiotensin positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration response to angiotensin activation of MAPK activity angiogenesis neural tube formation transcription, DNA-templated regulation of transcription, DNA-templated protein phosphorylation phosphorylation positive regulation of JNK cascade negative regulation of necroptotic process negative regulation of ripoptosome assembly involved in necroptotic process regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process negative regulation of apoptotic signaling pathway activation of MAPKK activity activation of NF-kappaB-inducing kinase activity histone H3 acetylation
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