Phospho-SMAD2/SMAD3 (Ser465, Ser467, Ser423, Ser425) Recombinant Rabbit Monoclonal Antibody (240826D11), CoraLite® 594

RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transforming growth factor beta receptor binding protein binding phosphatase binding ubiquitin protein ligase binding type I transforming growth factor beta receptor binding identical protein binding SMAD binding metal ion binding tau protein binding RNA polymerase II sequence-specific DNA binding transcription factor binding co-SMAD binding I-SMAD binding R-SMAD binding disordered domain specific binding DNA-binding transcription factor binding transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding transcription corepressor binding transcription coactivator binding collagen binding beta-catenin binding zinc ion binding ligand-dependent nuclear receptor binding DEAD/H-box RNA helicase binding enzyme binding protein kinase binding chromatin DNA binding mineralocorticoid receptor binding sterol response element binding glucocorticoid receptor binding protein homodimerization activity ubiquitin binding bHLH transcription factor binding sequence-specific DNA binding promoter-specific chromatin binding

ureteric bud development in utero embryonic development endoderm formation mesoderm formation regionalization determination of left/right asymmetry in lateral mesoderm aortic valve morphogenesis pulmonary valve morphogenesis endocardial cushion morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated transforming growth factor beta receptor signaling pathway zygotic specification of dorsal/ventral axis gastrulation pattern specification process endoderm development mesoderm development heart development cell proliferation anatomical structure morphogenesis response to glucose post-embryonic development embryonic pattern specification anterior/posterior pattern specification positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial to mesenchymal transition regulation of transforming growth factor beta receptor signaling pathway insulin secretion cell differentiation negative regulation of ossification lung development positive regulation of BMP signaling pathway pancreas development primary miRNA processing activin receptor signaling pathway organ growth intracellular signal transduction nodal signaling pathway cell fate commitment negative regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter paraxial mesoderm morphogenesis developmental growth embryonic foregut morphogenesis embryonic cranial skeleton morphogenesis regulation of multicellular organismal process pericardium development SMAD protein signal transduction mesenchyme development trophoblast cell migration secondary palate development response to cholesterol response to transforming growth factor beta odontoblast differentiation negative regulation of transcription from RNA polymerase II promoter MAPK cascade skeletal system development osteoblast differentiation response to hypoxia somitogenesis release of cytochrome c from mitochondria liver development heart looping osteoblast development immune system development regulation of transcription from RNA polymerase II promoter apoptotic process immune response JNK cascade negative regulation of cell proliferation regulation of striated muscle tissue development signal transduction involved in regulation of gene expression negative regulation of cell growth adrenal gland development positive regulation of cell migration positive regulation of bone mineralization thyroid gland development positive regulation of chondrocyte differentiation developmental process positive regulation of interleukin-1 beta production regulation of transforming growth factor beta2 production positive regulation of transforming growth factor beta3 production negative regulation of osteoblast proliferation wound healing T cell activation negative regulation of protein catabolic process positive regulation of protein import into nucleus negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process cell-cell junction organization positive regulation of nitric oxide biosynthetic process negative regulation of fat cell differentiation negative regulation of osteoblast differentiation regulation of epithelial cell proliferation negative regulation of inflammatory response regulation of immune response protein stabilization positive regulation of positive chemotaxis negative regulation of cytosolic calcium ion concentration positive regulation of stress fiber assembly regulation of mitochondrial membrane potential positive regulation of focal adhesion assembly transdifferentiation positive regulation of SMAD protein import into nucleus negative regulation of wound healing negative regulation of lung blood pressure lens fiber cell differentiation cellular response to glucose stimulus cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus positive regulation of canonical Wnt signaling pathway apoptotic signaling pathway extrinsic apoptotic signaling pathway cellular response to virus transforming growth factor beta receptor superfamily signaling pathway positive regulation of extracellular matrix assembly regulation of miRNA transcription negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of cardiac muscle hypertrophy in response to stress response to angiotensin