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DDX5 Monoclonal Antibody (2D3D2), CoraLite® 594

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DDX5 Monoclonal Antibody (2D3D2), CoraLite® 594

Product Details

CL59467025100UL

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-

Flow Cytometry (Flow)

0.2 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2D3D2

Conjugate

CoraLite® 594 CoraLite® 594 CoraLite® 594

Excitation/Emission Max

593/614 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 0.5% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles, store in dark

Shipping conditions

Wet ice

Target Information

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP-dependent RNA helicase DDX5; D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 5; ddx5 gene protein; DEAD (Asp-Glu-Ala-Asp) box helicase 5; DEAD (Asp-Glu-Ala-Asp) box polypeptide 5; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 5; DEAD box protein 5; DEAD box RNA helicase DEAD1; DEAD box-5; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD); DKFZp434E109; DKFZp686J01190; mDEAD1; MGC118083; p68 RNA helicase; Probable ATP-dependent RNA helicase DDX5; RNA helicase p68; RP23-247J12.4; unnamed protein product

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Gene Aliases: 2600009A06Rik; DDX5; G17P1; HELR; HLR1; HUMP68; p68

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UniProt ID: (Human) P17844

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Entrez Gene ID: (Human) 1655, (Mouse) 13207, (Rat) 287765

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Function(s)
nucleotide binding nucleic acid binding RNA binding RNA helicase activity mRNA binding mRNA 3'-UTR binding helicase activity protein binding calmodulin binding ATP binding hydrolase activity ATPase activity enzyme binding MH2 domain binding pre-mRNA binding ribonucleoprotein complex binding SMAD binding calcium-dependent protein binding androgen receptor binding R-SMAD binding primary miRNA binding promoter-specific chromatin binding transcription cofactor activity transcription coactivator activity ATP-dependent RNA helicase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides estrogen receptor binding poly(A) RNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter alternative mRNA splicing, via spliceosome regulation of alternative mRNA splicing, via spliceosome mRNA splicing, via spliceosome nuclear-transcribed mRNA catabolic process epithelial to mesenchymal transition regulation of transcription from RNA polymerase II promoter mRNA processing RNA splicing mRNA transcription BMP signaling pathway intracellular estrogen receptor signaling pathway androgen receptor signaling pathway primary miRNA processing positive regulation of DNA damage response, signal transduction by p53 class mediator regulation of viral genome replication myoblast differentiation regulation of osteoblast differentiation rhythmic process regulation of androgen receptor signaling pathway pri-miRNA transcription from RNA polymerase II promoter intrinsic apoptotic signaling pathway by p53 class mediator regulation of miRNA transcription regulation of skeletal muscle cell differentiation in utero embryonic development transcription, DNA-templated regulation of transcription, DNA-templated circadian rhythm RNA secondary structure unwinding positive regulation of intracellular estrogen receptor signaling pathway positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter metabolic process
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