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Proteintech
ERO1L Monoclonal Antibody (1G12E11), CoraLite® 594
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
CL59467416100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1G12E11
Conjugate
CoraLite® 594
CoraLite® 594
CoraLite® 594
Excitation/Emission Max
593/614 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Wet ice
Target Information
ERO1L (endoplasmic oxidoreductin-1-like protein) is localized in ER membrane as peripheral membrane protein on the lumenal side. Its association with ERP44 is essential for its retention in the ER and is unique in coupling oxygen reduction to de novo disulfides formation. The ERO1L enzyme is broadly distributed at low levels in several tissues with highest levels in the upper digestive tract and is stimulated by hypoxia via HIF-signaling. ERO1L generally exists as monomer, but has the ability to function as monomer or homodimer and interacts with PDILT. After translation, ERO1L gets n-glycosylated and the disulfide bonds constitute the redox-active center whereby the Cys-94/Cys-99 disulfide bond accepts an electron from P4HB followed by funneling the same to the active site disulfide Cys-394/Cys-397. ERO1L acts by oxidizing directly to P4HB/PDI isomerase through direct disulfide exchange and associates with ERP44. ERO1L is implicated in immunoglobulin folding, oxidative stress, release of unfolded cholera toxin from reduced P4HB/PDI upon Vibrio cholerae infection, and plays a key role in ER stress-induced CHOP-dependent apoptosis through inositol 1,4,5-trisphosphate receptor IP3R1 activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: endoplasmic oxidoreductin-1-like protein; endoplasmic reticulum oxidation 1; endoplasmic reticulum oxidoreductase alpha; endoplasmic reticulum oxidoreductin-1-like protein; ero1; ERO1 homolog; ERO1-L; ERO1-L-alpha; ERO1-like; Ero1l; GIIG11; global ischemia-induced protein 11; oxidoreductin-1-L-alpha; splice variant; unnamed protein product
Gene Aliases: ERO1-alpha; ERO1-L; ERO1-L-alpha; Ero1alpha; ERO1L; ERO1LA
UniProt ID: (Human) Q96HE7, (Rat) Q8R4A1, (Mouse) Q8R180
Entrez Gene ID: (Human) 30001, (Rat) 171562, (Mouse) 50527
protein folding
response to oxidative stress
transforming growth factor beta receptor signaling pathway
skeletal muscle tissue development
peptidyl-proline hydroxylation to 4-hydroxy-L-proline
L-ascorbic acid metabolic process
extracellular matrix organization
collagen fibril organization
endoplasmic reticulum unfolded protein response
protein folding in endoplasmic reticulum
response to endoplasmic reticulum stress
cell redox homeostasis
brown fat cell differentiation
release of sequestered calcium ion into cytosol
protein maturation
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to hypoxia
response to temperature stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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