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Proteintech
GNAS Monoclonal Antibody (1A9C10), CoraLite® Plus 647
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FIGURE: 1 / 1
GNAS Antibody (CL647-66253) in Flow
1X10^6 MCF-7 cells were intracellularly stained with 0.2 µg CoraLite® Plus 647 Anti-Human GNAS (CL647-66253, Clone:1A9C10) (red), or 0.2 µg isotype control (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL647-66253
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1A9C10
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
654/674 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: ERRKWIQCFN DVTAIIFVVA SSSYNMVIRE DNQTNRLQEA LNLFKSIWNN RWLRTISVIL FLNKQDLLAE KVLAGKSKIE DYFPEFARYT TPEDATPEPG EDPRVTRAKY FIRDEFLRIS TASGDGRHYC YPHFTCAVDT ENIRRVFNDC RDIIQRMHLR QYELL
Target Information
Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseous heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. This gene has a highly complex imprinted expression pattern. It encodes maternally, paternally, and biallelically expressed proteins which are derived from alternatively spliced transcripts with alternate 5' exons. Each of the upstream exons is within a differentially methylated region, commonly found in imprinted genes. However, the close proximity (14 kb) of two oppositely expressed promoter regions is unusual. In addition, one of the alternate 5' exons introduces a frameshift relative to the other transcripts, resulting in one isoform which is structurally unrelated to the others. An antisense transcript exists, and may regulate imprinting in this region. Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal dominant inheritance pattern requiring maternal transmission for full penetrance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adenylate cyclase-stimulating G alpha protein; alpha-stimulatory subunit of GTP-binding protein; Alternative gene product encoded by XL-exon; dJ309F20.1.1; dJ806M20.3.3; Extra large alphas protein; G protein; G protein subunit alpha S; GNSA1; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide regulatory protein; guanine nucleotide-binding protein alpha subunit; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; guanine nucleotide-binding protein G(s), alpha subunit; guanine nucleotide-binding protein, alpha-stimulating activity polypeptide 1; MGC33735; NESP55; NESP55; large dense core vesicle secretory protein; Neuroendocrine secretory protein 55; OTTHUMP00000031742; OTTHUMP00000196026; OTTHUMP00000196030; PHP1C; Protein ALEX; RP4-543J19.4; secretogranin VI; unnamed protein product; XLalphas; XLas
Gene Aliases: AHO; AIMAH1; C20orf45; GNAS; GNAS1; GPSA; GSA; GSP; NESP; NESP55; PITA3; POH; PORGSA1; SCG6; SgVI
UniProt ID: (Human) Q5JWF2
Entrez Gene ID: (Pig) 100049657, (Human) 2778
GTP binding
adenylate cyclase activator activity
metal ion binding
nucleotide binding
GTPase activity
obsolete small monomeric GTPase activity
insulin-like growth factor receptor binding
protein binding
adenylate cyclase regulator activity
hydrolase activity
guanyl nucleotide binding
G-protein beta/gamma-subunit complex binding
beta-2 adrenergic receptor binding
D1 dopamine receptor binding
mu-type opioid receptor binding
ionotropic glutamate receptor binding
corticotropin-releasing hormone receptor 1 binding
heterotrimeric G-protein
adenylate cyclase-activating G-protein coupled receptor signaling pathway
positive regulation of GTPase activity
positive regulation of cAMP-mediated signaling
adenylate cyclase-activating adrenergic receptor signaling pathway
negative regulation of inflammatory response to antigenic stimulus
renal water homeostasis
signal transduction
G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
adenylate cyclase-activating dopamine receptor signaling pathway
adenylate cyclase-activating serotonin receptor signaling pathway
female pregnancy
sensory perception of chemical stimulus
sensory perception of smell
protein secretion
regulation of signal transduction
regulation of skeletal muscle contraction
response to prostaglandin E
negative regulation of multicellular organism growth
intracellular transport
developmental growth
positive regulation of phagocytosis
regulation of insulin secretion
cognition
bone development
hair follicle placode formation
platelet aggregation
response to parathyroid hormone
cellular response to glucagon stimulus
cellular response to prostaglandin E stimulus
cellular response to acidic pH
cellular response to catecholamine stimulus
vascular endothelial cell response to laminar fluid shear stress
positive regulation of cold-induced thermogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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