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EIF3L Monoclonal Antibody (1B11A10), CoraLite® Plus 647
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FIGURE: 1 / 1
EIF3L Antibody (CL647-67719) in Flow
1x10^6 HeLa cells were intracellularly stained with 0.8 µg CoraLite® Plus 647 Anti-Human EIF3L (CL647-67719, Clone: 1B11A10) (red), or 0.8 µg CoraLite® Plus 647 Mouse IgG2a Isotype Control (C1.18.4) (CL647-65208, Clone: C1.18.4) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL647-67719
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1B11A10
Immunogen
EIF3L fusion protein Ag26680
Conjugate
Excitation/Emission Max
654/674 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SVAGEYGRH SLYKMLGYFS LVGLLRLHSL LGDYYQAIKV LENIELNKKS MYSRVPECQV TTYYYVGFAY LMMRRYQDAI RVFANILLYI QRTKSMFQRT TYKYEMINKQ NEQMHALLAI ALTMYPMRID ESIHLQLREK YGDKMLRMQK GDPQVYEELF SYSCPKFLSP VVPNYDNVHP NYHKEPFLQQ LKVFSDEVQQ QAQLSTIRSF LKLYTTMPVA KLAGFLDLTE QEFRIQLLVF KHKMKNLVWT SGISALDGEF QSASEVDFYI DKDMIHIADT KVARRYGDFF IRQIHKFEEL NRTLKKMGQR P
Target Information
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 66 kDa tyrosine-rich heat shock protein; 67 kDa polymerase-associated factor; dJ1014D13.1; eIEF associated protein HSPC021; eIF3l; Eukaryotic translation initiation factor 3 subunit 6-interacting protein; Eukaryotic translation initiation factor 3 subunit E-interacting protein; Eukaryotic translation initiation factor 3 subunit L; eukaryotic translation initiation factor 3, subunit 6 interacting protein; HSP-66Y; PAF67; unnamed protein product
Gene Aliases: 0610011H21Rik; D15N1e; EIF3EIP; Eif3ip; EIF3L; EIF3S11; EIF3S6IP; HSP-66Y; HSPC021; HSPC025; MSTP005; PAF67
UniProt ID: (Human) Q9Y262, (Mouse) Q8QZY1
Entrez Gene ID: (Human) 51386, (Mouse) 223691, (Rat) 300069
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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