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Proteintech
ACAP1 Recombinant Rabbit Monoclonal Antibody (230370E1), CoraLite® Plus 750
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Product Details
CL750-82967
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
230370E1
Immunogen
ACAP1 fusion protein Ag34309
Conjugate
Excitation/Emission Max
755/780 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: RAGYRGRALD YALQINVIED KRKFDIMEFV LRLVEAQATH FQQGHEELSR LSQYRKELGA QLHQLVLNSA REKRDMEQRH VLLKQKELGG EEPEPSLREG PGGLVMEG
Target Information
ACAP1, also known as Centaurin-beta-1 (CENTB1), is a 740 amino acid containing transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain and a PH domain that binds to phospholipids. ACAP1, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6), is required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. It mediates CENTB1-binding to phosphatidylinositol 3,5-bisphosphate (PIP2) or phosphatidylinositol 3,4,5-trisphosphate (PIP3) containing membranes. Along with ACAP2, ACAP1 is recruited to platelet-derived growth factor (PDGF) induced dorsal membrane ruffles in NIH 3T3 mouse fibroblasts, while over expression inhibited ruffle formation. It is widely expressed in most tissues with high expression in lung and spleen and low expression in heart, kidney, liver and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Arf GAP with coiled coil, ANK repeat and PH domains 1; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; centaurin beta 1; Centaurin-beta-1; Cnt-b1; KIAA0050
Gene Aliases: ACAP1; CENTB1; KIAA0050
UniProt ID: (Human) Q15027
Entrez Gene ID: (Human) 9744
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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