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Proteintech
CLASP2 Polyclonal Antibody
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Product Details
12942-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CLASP2 Fusion Protein Ag4012 (1-308 aa encoded by BC029035)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MRRLICKRI CDYKSFDDEE SVDGNRPSSA ASAFKVPAPK TSGNPANSAR KPGSAGGPKV GGASKEGGAG AVDEDDFIKA FTDVPSIQIY SSRELEETLN KIREILSDDK HDWDQRANAL KKIRSLLVAG AAQYDCFFQH LRLLDGALKL SAKDLRSQVV REACITVAHL STVLGNKFDH GAEAIVPTLF NLVPNSAKVM ATSGCAAIRF IIRHTHVPRL IPLITSNCTS KSVPVRRRSF EFLDLLLQEW QTHSLERHAA VLVETIKKGI HDADAEARVE ARKTYMGLRN HFPGEAETLY NSLEPSYQK (1-308 aa encoded by BC029035 )
Target Information
CLASP2 is microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CLASP2-delta; CLASP2-epsilon; CLASP2alpha; CLASP2gamma; CLIP-associating protein 2; CLIP-associating protein CLASP2; Cytoplasmic linker-associated protein 2; hOrbit2; multiple asters (Mast)-like homolog 2; Protein Orbit homolog 2; unnamed protein product
Gene Aliases: 1500004F14Rik; 8030404L10Rik; C77448; CLASP2; CLASP2beta; KIAA0627; mKIAA0627
UniProt ID: (Human) O75122, (Mouse) Q8BRT1
Entrez Gene ID: (Human) 23122, (Mouse) 76499
microtubule cytoskeleton organization
vesicle targeting
microtubule nucleation
negative regulation of microtubule depolymerization
Golgi organization
mitotic spindle organization
establishment or maintenance of cell polarity
exit from mitosis
regulation of gastrulation
positive regulation of epithelial cell migration
regulation of epithelial to mesenchymal transition
regulation of axon extension
microtubule organizing center organization
regulation of microtubule polymerization or depolymerization
regulation of microtubule polymerization
regulation of microtubule-based process
regulation of actin cytoskeleton organization
microtubule anchoring
platelet-derived growth factor receptor-beta signaling pathway
establishment of mitotic spindle localization
positive regulation of exocytosis
cell division
negative regulation of stress fiber assembly
regulation of focal adhesion assembly
negative regulation of focal adhesion assembly
basement membrane organization
positive regulation of extracellular matrix disassembly
mitotic spindle assembly
presynaptic cytoskeleton organization
negative regulation of wound healing, spreading of epidermal cells
positive regulation of basement membrane assembly involved in embryonic body morphogenesis
cell cycle
mitotic nuclear division
cell migration
meiotic cell cycle
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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