The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer.
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Protein Aliases: CaCC-3; Calcium-activated chloride channel family member 2; Calcium-activated chloride channel family member 5; Calcium-activated chloride channel protein 3; Calcium-activated chloride channel regulator 2; Calcium-activated chloride channel regulator 2, 109 kDa form; Calcium-activated chloride channel regulator 2, 35 kDa form; calcium-activated chloride channel-2; chloride channel calcium activated 5; chloride channel regulator 2; chloride channel, calcium activated, family member 2; CLCA family member 2, chloride channel regulator; FLJ97885; hCaCC-3; hCLCA2; mCLCA5
Gene Aliases: 4732440A06; AI586120; CACC; CaCC-3; CACC3; CLCA2; Clca5; CLCRG2