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CLCC1 Antibody (PA5-120569) in IHC (P)
Immunohistochemistry analysis of CLCC1 in paraffin-embedded human colon carcinoma. Samples were incubated with CLCC1 Polyclonal antibody (Product # PA5-120569) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-120569
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 302-501 of human CLCC1 (NP_055942.1).
Conjugate
Form
Liquid
Concentration
0.43 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2914141
Product Specific Information
Positive test controls include: U-87MG, 22Rv1, Mouse spleen.
Immunogen sequence: GAGKSVHVLR HIGGPESEPP QALRPRDRRR QEEIDYRPDG GAGDADFHYR GQMGPTEQGP YAKTYEGRRE ILRERDVDLR FQTGNKSPEV LRAFDVPDAE AREHPTVVPS HKSPVLDTKP KETGGILGEG TPKESSTESS QSAKPVSGQD TSGNTEGSPA AEKAQLKSEA AGSPDQGSTY SPARGVAGPR GQDPVSSPCG
Target Information
Neurofibromin is a member of the GTPase-activating (GAP) class of proteins. These proteins enhance the GTPase activity of signaling G-Proteins like Ras. The NF1 gene is also classified as a tumor suppressor gene, and many studies have shown that mutations at the NF1 locus produce neurofibromas, rhabdomyosarcomas, leimyosarcomas, mental retardation and memory deficiency. Neurofibromin has also been associated with the intermediated filaments of the cytoskeleton. NF1 is expressed at its highest levels during periods of desmosome formation and mutations of NF1 produce variable cell sizes and morphologies.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: chloride channel CLIC-like 1; Chloride channel CLIC-like protein 1; ER anion channel 1; ERAC1; Mid-1-related chloride channel 1; Mid-1-related chloride channel protein; Mid-1-related chloride channel protein 1
Gene Aliases: CLCC1; KIAA0761; MCLC
UniProt ID: (Human) Q96S66, (Mouse) Q99LI2
Entrez Gene ID: (Human) 23155, (Mouse) 229725
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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