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Product Details
PA5-53036
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CLCC1. Recombinant protein control fragment (Product #RP-90165).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2639852
Product Specific Information
Immunogen sequence: HDDDWIDPTD MLNYDAASGT MRKSQAKYGI SGEKDVSPDL SCADEISECY HKLDSLTYKI DECEKKKRED YESQSNPVFR RYLNKILIEA GKLGLL
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 81%.
Target Information
Neurofibromin is a member of the GTPase-activating (GAP) class of proteins. These proteins enhance the GTPase activity of signaling G-Proteins like Ras. The NF1 gene is also classified as a tumor suppressor gene, and many studies have shown that mutations at the NF1 locus produce neurofibromas, rhabdomyosarcomas, leimyosarcomas, mental retardation and memory deficiency. Neurofibromin has also been associated with the intermediated filaments of the cytoskeleton. NF1 is expressed at its highest levels during periods of desmosome formation and mutations of NF1 produce variable cell sizes and morphologies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: chloride channel CLIC-like 1; Chloride channel CLIC-like protein 1; ER anion channel 1; ERAC1; Mid-1-related chloride channel protein; Mid-1-related chloride channel protein 1
Gene Aliases: CLCC1; KIAA0761; MCLC
UniProt ID: (Human) Q96S66
Entrez Gene ID: (Human) 23155
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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