This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: VVSRDSERLI GFAQRRELIL AIKNARQRQE GIVSNSIMYF TEEPPELPAN SPHPLKLRRI LNLS
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 100%.
The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. The genes encoding human CLC-1 through CLC-7 map to chromosomes 7, 3q26, 4q32, Xp22, Xp11, 1p36 and 16p13, respectively. CLC-1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC-1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC-2 is highly expressed in the epithelia of several organs including lung, which suggests CLC-2 may be a possible therapeutic target for cystic fibrosis. CLC-3 expression is particularly abundant in neuronal tissue, while CLC-4 expression is evident in skeletal and cardiac muscle as well as brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: chloride channel 4; Chloride channel protein 4; chloride channel, voltage-sensitive 4; Chloride transporter ClC-4; CLC 4; ClC-4; H(+)/Cl(-) exchange transporter 4; MGC163150
Gene Aliases: ClC-4; ClC-4A; CLC4; CLCN4
UniProt ID: (Human) P51793
Entrez Gene ID: (Human) 1183