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Invitrogen
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In Western blots, approximately 15% cross-reactivity with recombinant mouse DCIR is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
The CLEC4B gene encodes a member of the C-type lectin domain family and plays a significant role in immune system regulation, particularly involving the activation and modulation of neutrophils. CLEC4B is expressed in various immune cells, including neutrophils, where it contributes to controlling inflammatory responses and immune activation. It has been identified as a regulator of bystander activation of autoreactive and potentially pathogenic T cells, suggesting its involvement in limiting chronic inflammation. This gene participates in glycan recognition, which can induce the production of reactive oxygen species, thereby protecting tissues from oxidative stress and inflammatory damage. The role of CLEC4B extends to the regulation of neutrophil availability and function, exerting additive effects with other genes to modulate immune responses. CLEC4B's function in immune homeostasis presents potential therapeutic implications, particularly in autoimmune diseases and conditions involving excessive inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: antigen presenting cell lectin-like receptor A2; C-type lectin domain family 4, member b1; dendritic cell immunoactivating receptor
Gene Aliases: 1810046I24Rik; Aplra2; Clec4b; DCAR; Dcar2; DCARbeta
Entrez Gene ID: (Mouse) 69810
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