Search
Proteintech
CLEC4M Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
22003-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CLEC4M Fusion Protein Ag4523 (1-399 aa encoded by BC038851)
Conjugate
Form
Liquid
Concentration
0.38 mg/mL
Amount
57 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSDSKEPRV QQLGLLEEDP TTSGIRLFPR DFQFQQIHGH KSSTGCLGHG ALVLQLLSFM LLAGVLVAIL VQVSKVPSSL SQEQSEQDAI YQNLTQLKAA VGELSEKSKL QEIYQELTQL KAAVGELPEK SKLQEIYQEL TRLKAAVGEL PEKSKLQEIY QELTRLKAAV GELPEKSKLQ EIYQELTRLK AAVGELPEKS KLQEIYQELT ELKAAVGELP EKSKLQEIYQ ELTQLKAAVG ELPDQSKQQQ IYQELTDLKT AFERLCRHCP KDWTFFQGNC YFMSNSQRNW HDSVTACQEV RAQLVVIKTA EEQNFLQLQT SRSNRFSWMG LSDLNQEGTW QWVDGSPLSP SFQRYWNSGE PNNSGNEDCA EFSGSGWNDN RCDVDNYWIC KKPAACFRDE (1-399 aa encoded by BC038851)
Target Information
CLEC4M is a type II integral membrane protein that is 77% identical to CD209 antigen, a HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene encodes a type II integral membrane protein that is 77% identical to CD209 antigen, a HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C-type lectin; C-type lectin domain family 4 member M; CD209 antigen-like protein 1; CD299; CD299 antigen; DC-SIGN-related protein; DC-SIGN2; DC-SIGNR; Dendritic cell-specific ICAM-3-grabbing non-integrin 2; L-SIGN; liver/lymph node-specific ICAM-3 grabbing non-integrin; Liver/lymph node-specific ICAM-3-grabbing non-integrin; mannose binding C-type lectin DC-SIGNR; MGC129964; MGC47866; type II integral membrane protein; unnamed protein product
Gene Aliases: CD209L; CD209L1; CD299; CLEC4M; DC-SIGN2; DC-SIGNR; DCSIGNR; HP10347; L-SIGN; LSIGN
UniProt ID: (Human) Q9H2X3
Entrez Gene ID: (Human) 10332
adaptive immune response
immune system process
endocytosis
immune response
leukocyte cell-cell adhesion
cell-cell recognition
virion attachment to host cell
receptor-mediated endocytosis of virus by host cell
viral genome replication
antigen processing and presentation
intracellular signal transduction
innate immune response
viral entry into host cell
receptor-mediated virion attachment to host cell
peptide antigen transport
intracellular transport of virus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support