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Bioss
CLEC5A Polyclonal Antibody
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Product Details
BS-2663R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from mouse CLEC5A, amino acids 101-190.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation. Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5; C-type lectin domain family 5 member A; C-type lectin domain family 5, member A; C-type lectin superfamily member 5; MDL-1; Myeloid DAP12-associating lectin 1; myeloid DAP12-associating lectin-1; type II transmembrane protein MDL-1
Gene Aliases: CLEC5A; CLECSF5; Ly100; MDL-1; MDL1
UniProt ID: (Human) Q9NY25, (Mouse) Q9R007
Entrez Gene ID: (Human) 23601, (Rat) 679787, (Mouse) 23845
osteoblast development
cellular defense response
signal transduction
myeloid cell differentiation
negative regulation of myeloid cell apoptotic process
negative regulation of apoptotic process
innate immune response
viral entry into host cell
positive regulation of cytokine secretion
response to virus
immune system process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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