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Invitrogen
CLIC5 Polyclonal Antibody
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CLIC5 Antibody (PA5-14533) in IHC (P)
Immunohistochemistry analysis of CLIC5 in formalin-fixed and paraffin-embedded Human colon carcinoma tissue. Samples were incubated with CLIC5 polyclonal antibody (Product # PA5-14533) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Details
PA5-14533
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Human recombinant CLIC5 protein.
Conjugate
Form
Liquid
Concentration
1.7 mg/mL
Purification
Size-exclusion - Dialysis, Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Clic5 encodes a protein that is required for normal hearing and is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Clic5 can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Clic5 may play a role in the regulation of transepithelial ion absorption and secretion, and is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. The Clic5 gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The protein encoded by Clic5 associates with actin-based cytoskeletal structures and may also play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for the Clic5 gene. Diseases associated with CLIC5 include Deafness, Autosomal Recessive 103 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chloride intracellular channel protein 5; Glutaredoxin-like oxidoreductase CLIC5
Gene Aliases: CLIC5; DFNB102; DFNB103; MST130; MSTP130
UniProt ID: (Human) Q9NZA1
Entrez Gene ID: (Human) 53405
diet induced thermogenesis
glutathione metabolic process
transport
chloride transport
female pregnancy
sensory perception of sound
protein localization
regulation of ion transmembrane transport
neuromuscular process controlling balance
auditory receptor cell stereocilium organization
chloride transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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