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Invitrogen
CLIP1 Polyclonal Antibody
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Product Details
PA5-20545
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 17 amino acid peptide from near the carboxy terminus of human CLIP170.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is rat brain tissue lysate.
PA5-20545 can be used with blocking peptide PEP-0665.
Target Information
CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAP-Gly domain-containing linker protein 1; Clip 170; CLIP-170; Cytoplasmic linker protein 1; Cytoplasmic linker protein 170; Cytoplasmic linker protein 170 alpha-2; cytoplasmic linker protein 50; cytoplasmic linker protein CLIP-170; MGC131604; Reed-Steinberg cell-espressed intermediate filament-associated protein; Reed-Sternberg intermediate filament-associated protein; Restin; restin (Reed-Steinberg cell-espressed intermediate filament-associated protein); restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)
Gene Aliases: 1110007I12Rik; 4631429H07Rik; AV017631; C81039; CLIP; CLIP-170; CLIP1; CLIP170; Clip50; CYLN1; Kiaa4046; mKIAA4046; restin; RSN
UniProt ID: (Human) P30622, (Mouse) Q922J3, (Rat) Q9JK25
Entrez Gene ID: (Human) 6249, (Mouse) 56430, (Rat) 65201
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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