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Proteintech
CLOCK Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
18094-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CLOCK Fusion Protein Ag12826 (1-351 aa encoded by BC041878)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MLFTVSCSK MSSIVDRDDS SIFDGLVEED DKDKAKRVSR NKSEKKRRDQ FNVLIKELGS MLPGNARKMD KSTVLQKSID FLRKHKEITA QSDASEIRQD WKPTFISNEE FTQLMLEALD GFFLAIMTDG SIIYVSESVT SLLEHLPSDL VDQSIFNFIP EGEHSEVYKI LSTHLLESDS LTPEYLKSKN QLEFCCHMLR GTIDPKEPST YEYVKFIGNF KSLNSVSSSA HNGFEGTIQR THRPSYEDRV CFVATVRLAT PQFIKEMCTV EEPNEEFTSR HSLEWKFLFL DHRAPPIIGY LPFEVLGTSG YDYYHVDDLE NLAKCHEHLM QYGKGKSCYY RFLTKGQQWI WL (1-351 aa encoded by BC041878)
Target Information
This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: circadian locomoter output cycles kaput protein; class E basic helix-loop-helix protein 8; clock homolog; KIAA0334; unnamed protein product
Gene Aliases: bHLHe8; KAT13D
UniProt ID: (Human) O15516
Entrez Gene ID: (Human) 9575
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
histone acetyltransferase activity
protein binding
chromatin DNA binding
sequence-specific DNA binding
protein dimerization activity
peptide-lysine-N-acetyltransferase activity
E-box binding
sequence-specific double-stranded DNA binding
DNA damage checkpoint
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
protein acetylation
signal transduction
spermatogenesis
circadian rhythm
photoperiodism
circadian regulation of gene expression
regulation of hair cycle
regulation of circadian rhythm
positive regulation of circadian rhythm
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of inflammatory response
regulation of insulin secretion
response to redox state
cellular response to ionizing radiation
regulation of type B pancreatic cell development
negative regulation of glucocorticoid receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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