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Product Specifications | |
---|---|
Species Reactivity |
Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
KLH conjugated synthetic peptide derived from mouse CLPS, amino acids 41-112. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Protein A |
Storage buffer |
PBS with 1% BSA, 50% glycerol |
Contains |
0.09% sodium azide |
Storage conditions |
-20°C |
The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: COL; Colipase
Gene Aliases: 2200003J09Rik; Clps; COLQ
UniProt ID: (Mouse) Q9CQC2, (Rat) P17084
Entrez Gene ID: (Mouse) 109791, (Rat) 25680
Molecular Function:
protein-binding activity modulator
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