Peptide sequence: KPWLEPTYHG IVTENDNTVL LDPPLIALDK DAPLRFAESF EVTVTKEGEI
Sequence homology: Cow: 82%; Dog: 92%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%
CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.
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Protein Aliases: Alc-alpha; Alcadein-alpha; Alzheimer-related cadherin-like protein; C-terminal fragment 1-alpha; cadherin-related family member 12; Calsyntenin-1; CTF1-alpha; FLJ32258; Non-classical cadherin XB31alpha; SAlc-alpha; Soluble Alc-alpha
Gene Aliases: ALC-ALPHA; alcalpha1; alcalpha2; CDHR12; CLSTN1; CS1; CST-1; CSTN1; KIAA0911; PIK3CD; XB31alpha
UniProt ID: (Human) O94985
Entrez Gene ID: (Human) 22883