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Product Details
25877-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CMPK2 fusion protein Ag22885
Conjugate
Form
Liquid
Concentration
0.65 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MAFARRLLRG PLSGPLLGRR GVCAGAMAPP RRFVLELPDC TLAHFALGAD APGDADAPDP RLAALLGPPE RSYSLCVPVT PDAGCGARVR AARLHQRLLH QLRRGPFQRC QLLRLLCYCP GGQAGGAQQG FLLRDPLDDP DTRQALLELL GACQEAPRPH LGEFEADPRG QLWQRLWEVQ DGRRLQVGCA QVVPVPEPPL HPVVPDLPSS VVFPDREAAR AVLEECTSFI PEARAVLDLV DQCPKQIQKG KFQVVAIEGL DATGKTTVTQ SVADSLKAVL LKSPPSCIGQ WRKIFDDEPT IIRRAFYSLG NYIVASEIAK ESAKSPVIVD RYWHSTATYA IATEVS
Target Information
UMP-CMP kinase 2 (CMPK2) is the first nucleoside monophosphate kinase that has been identified in human mitochondria. It is a component of the salvage pathway for nucleotide synthesis that may participate in terminal differentiation of monocytic cells. There are two distinct domains of CMPK2: the N-terminal domain with unknown function and the C-terminal domain with the kinase function, suggesting that CMPK2 may be a bifunctional protein with other biological functions in addition to its UMP-CMP kinase activity. CMPK2 may participate in dUTP and dCTP synthesis and is responsible for phosphorylation of dCMP and dUMP in mitochondria. CMPK2 is actively involved in macrophage activation and the inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; cytidylate kinase 2; mitochondrial UMP-CMP kinase; Nucleoside-diphosphate kinase; thymidine monophosphate kinase 2; thymidylate kinase family LPS-inducible member; thymidylate kinase homologue; Thymidylate kinase LPS-inducible member; TYKi; UMP-CMP kinase 2, mitochondrial; UMP/CMP kinase
Gene Aliases: 1200004E04Rik; CMPK2; NDK; TDKI; TMPK2; TYKi; UMP-CMPK2
UniProt ID: (Human) Q5EBM0, (Mouse) Q3U5Q7
Entrez Gene ID: (Human) 129607, (Rat) 314004, (Mouse) 22169
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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