|Immunofluorescence (IF)||20 ug/mL|
|Immunohistochemistry (IHC)||20 ug/ml|
|Western Blot (WB)||1 ug/mL|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 19 amino acid synthetic peptide near the carboxy terminus of human CMPK2|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is rat lung tissue lysate.
PA5-34461 can be used with blocking peptide PEP-1503.
UMP-CMP kinase 2 (CMPK2) is the first nucleoside monophosphate kinase that has been identified in human mitochondria. It is a component of the salvage pathway for nucleotide synthesis that may participate in terminal differentiation of monocytic cells. There are two distinct domains of CMPK2: the N-terminal domain with unknown function and the C-terminal domain with the kinase function, suggesting that CMPK2 may be a bifunctional protein with other biological functions in addition to its UMP-CMP kinase activity. CMPK2 may participate in dUTP and dCTP synthesis and is responsible for phosphorylation of dCMP and dUMP in mitochondria. CMPK2 is actively involved in macrophage activation and the inflammatory response
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CMPK2; cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; Cytidine monophosphate UMP-CMP kinase 2; cytidylate kinase 2; mitochondrial UMP-CMP kinase; Nucleoside-diphosphate kinase; thymidine monophosphate kinase 2; thymidylate kinase family LPS-inducible member; thymidylate kinase homologue; Thymidylate kinase LPS-inducible member; TMPK2; TYKi; UMP-CMP kinase 2, mitochondrial; UMP-CMPK2; UMP/CMP kinase
Gene Aliases: 1200004E04Rik; CMPK2; NDK; TDKI; TMPK2; TYKi; UMP-CMPK2
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