Osenses

CNG4 Polyclonal Antibody

Product Details

OSC00173W-100UL

Applications

Tested Dilution

Publications

Western Blot (WB)

1:300-1:2,000

Immunohistochemistry (IHC)

1:300-1:2,000

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Mouse, Rat

Published species

Not Applicable

Host/Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from the n-terminal region of mouse CNG4 conjugated to an immunogenic carrier protein was used as the antigen

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Specificity of this antibody: CNGA4.

Target Information

Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The transcriptional landscape of the mammalian genome.

Science (New York, N.Y.)

Carninci P,Kasukawa T,Katayama S,Gough J,Frith MC,Maeda N,Oyama R,Ravasi T,Lenhard B,Wells C,Kodzius R,Shimokawa K,Bajic VB,Brenner SE,Batalov S,Forrest AR,Zavolan M,Davis MJ,Wilming LG,Aidinis V,Allen JE,Ambesi-Impiombato A,Apweiler R,Aturaliya RN,Bailey TL,Bansal M,Baxter L,Beisel KW,Bersano T,Bono H,Chalk AM,Chiu KP,Choudhary V,Christoffels A,Clutterbuck DR,Crowe ML,Dalla E,Dalrymple BP,de Bono B,Della Gatta G,di Bernardo D,Down T,Engstrom P,Fagiolini M,Faulkner G,Fletcher CF,Fukushima T,Furuno M,Futaki S,Gariboldi M,Georgii-Hemming P,Gingeras TR,Gojobori T,Green RE,Gustincich S,Harbers M,Hayashi Y,Hensch TK,Hirokawa N,Hill D,Huminiecki L,Iacono M,Ikeo K,Iwama A,Ishikawa T,Jakt M,Kanapin A,Katoh M,Kawasawa Y,Kelso J,Kitamura H,Kitano H,Kollias G,Krishnan SP,Kruger A,Kummerfeld SK,Kurochkin IV,Lareau LF,Lazarevic D,Lipovich L,Liu J,Liuni S,McWilliam S,Madan Babu M,Madera M,Marchionni L,Matsuda H,Matsuzawa S,Miki H,Mignone F,Miyake S,Morris K,Mottagui-Tabar S,Mulder N,Nakano N,Nakauchi H,Ng P,Nilsson R,Nishiguchi S,Nishikawa S,Nori F,Ohara O,Okazaki Y,Orlando V,Pang KC,Pavan WJ,Pavesi G,Pesole G,Petrovsky N,Piazza S,Reed J,Reid JF,Ring BZ,Ringwald M,Rost B,Ruan Y,Salzberg SL,Sandelin A,Schneider C,Schönbach C,Sekiguchi K,Semple CA,Seno S,Sessa L,Sheng Y,Shibata Y,Shimada H,Shimada K,Silva D,Sinclair B,Sperling S,Stupka E,Sugiura K,Sultana R,Takenaka Y,Taki K,Tammoja K,Tan SL,Tang S,Taylor MS,Tegner J,Teichmann SA,Ueda HR,van Nimwegen E,Verardo R,Wei CL,Yagi K,Yamanishi H,Zabarovsky E,Zhu S,Zimmer A,Hide W,Bult C,Grimmond SM,Teasdale RD,Liu ET,Brusic V,Quackenbush J,Wahlestedt C,Mattick JS,Hume DA,Kai C,Sasaki D,Tomaru Y,Fukuda S,Kanamori-Katayama M,Suzuki M,Aoki J,Arakawa T,Iida J,Imamura K,Itoh M,Kato T,Kawaji H,Kawagashira N,Kawashima T,Kojima M,Kondo S,Konno H,Nakano K,Ninomiya N,Nishio T,Okada M,Plessy C,Shibata K,Shiraki T,Suzuki S,Tagami M,Waki K,Watahiki A,Okamura-Oho Y,Suzuki H,Kawai J,Hayashizaki Y

Fri Sep 02 00:00:00 UTC 2005

Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation.

Science (New York, N.Y.)

Munger SD,Lane AP,Zhong H,Leinders-Zufall T,Yau KW,Zufall F,Reed RR

Fri Dec 07 00:00:00 UTC 2001

Bioinformatics

Protein Aliases: CNCalpha4, CNG5; cng channel; CNG channel alpha-4; CNG-4; CNG4; cyclic nucleotide gated cation channel; cyclic nucleotide-gated cation channel alpha 4; cyclic nucleotide-gated cation channel alpha-4; Cyclic nucleotide-gated channel alpha-4; cyclic nucleotide-gated olfactory channel subunit OCNC2; OCNC2; olfactory cyclic nucleotide-gated channel; Olfactory cyclic nucleotide-gated channel subunit 2

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Gene Aliases: Cgn2; Cnga4; rOCNC2

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UniProt ID: (Mouse) Q3UW12, (Rat) Q64359

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Entrez Gene ID: (Mouse) 233649, (Rat) 85258

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Function(s)

nucleotide binding ion channel activity intracellular cyclic nucleotide activated cation channel activity intracellular cAMP activated cation channel activity intracellular cGMP activated cation channel activity voltage-gated potassium channel activity cAMP binding cGMP binding ligand-gated ion channel

Process(es)

transport ion transport sensory perception of smell ion transmembrane transport regulation of ion transmembrane transport regulation of membrane potential response to stimulus protein heterotetramerization transmembrane transport potassium ion transmembrane transport cation transmembrane transport phototransduction, visible light

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CNG4 Polyclonal Antibody

Product Details

OSC00173W-100UL

Western Blot (WB)

Immunohistochemistry (IHC)

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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