Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection.
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Protein Aliases: cng channel; CNG channel alpha-4; cyclic nucleotide gated channel beta 2; Cyclic nucleotide-gated cation channel alpha-4; Cyclic nucleotide-gated channel alpha-4
Gene Aliases: CNCA2; CNG-4; CNG4; CNG5; CNGA4; CNGB2; OCNC2; OCNCb; OCNCBETA
UniProt ID: (Human) Q8IV77
Entrez Gene ID: (Human) 1262