Invitrogen

CNP Polyclonal Antibody

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CNP Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of CNP in human cerebellum using CNP Polyclonal Antibody (Product # PA5-57241) shows moderate to strong cytoplasmic positivity in Purkinje cells.

Product Details

Tested Applications

Dilution

Immunohistochemistry (IHC)

1:50-1:200

Product Specifications

Species Reactivity

Human

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CNP

Conjugate

Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2639960

Product Specific Information

Immunogen sequence: PKVPRTPPAE ELAEPQAAGG GQKKGDKAPG GGGANLKGDR SRLLRDLRVD TKSRAAWARL LQEHPNARKY KGANKKGLSK GCFGLKLDRI GSMSGLGC

Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 95%.

Target Information

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: C-type natriuretic peptide; CNP-22; CNP-29; CNP-53; CNP2; natriuretic peptide C; natriuretic peptide precursor C; natriuretic peptide precursor type C; NPPC

Gene Aliases: CNP; CNP2; NPPC

UniProt ID: (Human) P23582

Entrez Gene ID: (Human) 4880

Molecular Function: peptide hormone signaling molecule