Invitrogen

CNP Polyclonal Antibody

View all (7) CNP antibodies

Questions & Answers

Questions & Answers

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CNP Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of CNP in human cerebellum using CNP Polyclonal Antibody (Product # PA5-57241) shows moderate to strong cytoplasmic positivity in Purkinje cells.

CNP Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of CNP in human breast using CNP Polyclonal Antibody (Product # PA5-57241) shows moderate to strong cytoplasmic positivity in glandular cells.

CNP Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of CNP in human prostate using CNP Polyclonal Antibody (Product # PA5-57241) shows moderate to strong cytoplasmic positivity in basal cells.

CNP Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of CNP in human liver using CNP Polyclonal Antibody (Product # PA5-57241) shows very weak cytoplasmic positivity in hepatocytes.

Product Details

PA5-57241

Applications	Tested Dilution	Publications
Immunohistochemistry (IHC)	1:50-1:200	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Recombinant protein corresponding to Human CNP View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.3 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.2, with 40% glycerol
Contains	0.02% sodium azide
Storage conditions	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID	AB_2639960

Product Specific Information

Immunogen sequence: PKVPRTPPAE ELAEPQAAGG GQKKGDKAPG GGGANLKGDR SRLLRDLRVD TKSRAAWARL LQEHPNARKY KGANKKGLSK GCFGLKLDRI GSMSGLGC

Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 95%.

Target Information

NPPC (Natriuretic Peptide C) is a hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. The protein may also be vasoactive and natriuretic. It specifically binds and stimulates the cGMP production of the NPR2 receptor, and also binds the clearance receptor NPR3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C-type natriuretic peptide; CNP-22; CNP-29; CNP-53; INT3; natriuretic peptide precursor type C; NOTCH3

Gene Aliases: CNP; CNP2; NPPC

UniProt ID: (Human) P23582

Entrez Gene ID: (Human) 4880

Molecular Function: peptide hormone

ossification response to hypoxia growth plate cartilage chondrocyte differentiation growth plate cartilage chondrocyte proliferation cGMP biosynthetic process receptor guanylyl cyclase signaling pathway negative regulation of cell proliferation post-embryonic development regulation of cAMP metabolic process regulation of cGMP metabolic process positive regulation of cGMP biosynthetic process regulation of multicellular organism growth response to drug single organism reproductive process response to ethanol positive regulation of osteoblast differentiation positive regulation of vasodilation regulation of smooth muscle cell proliferation negative regulation of DNA metabolic process negative regulation of meiotic cell cycle negative regulation of oocyte maturation regulation of cardiac conduction

Process(es)

receptor binding hormone activity protein homodimerization activity peptide hormone receptor binding