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Product Details
PA5-70342
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the C-terminal region of CNP
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2690054
Product Specific Information
This target displays homology in the following species: Cow: 93%; Dog: 93%; Goat: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%; Sheep: 93%
Target Information
NPPC (Natriuretic Peptide C) is a hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. The protein may also be vasoactive and natriuretic. It specifically binds and stimulates the cGMP production of the NPR2 receptor, and also binds the clearance receptor NPR3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-type natriuretic peptide; CNP-22; CNP-29; CNP-53; INT3; natriuretic peptide precursor C; natriuretic peptide precursor type C; NOTCH3
Gene Aliases: CNP; lbab; Nppc
UniProt ID: (Mouse) Q61839
Entrez Gene ID: (Mouse) 18159
Molecular Function:
peptide hormone
ossification
growth plate cartilage chondrocyte differentiation
growth plate cartilage chondrocyte proliferation
cGMP biosynthetic process
receptor guanylyl cyclase signaling pathway
negative regulation of cell proliferation
post-embryonic development
regulation of cAMP metabolic process
regulation of cGMP metabolic process
positive regulation of cGMP biosynthetic process
regulation of multicellular organism growth
single organism reproductive process
positive regulation of osteoblast differentiation
positive regulation of vasodilation
animal organ development
regulation of blood vessel size
negative regulation of DNA metabolic process
negative regulation of meiotic cell cycle
negative regulation of oocyte maturation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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