PA1-744 detects cannabinoid receptor 2 (CB2) from human tissues.
PA1-744 has been successfully used in Western blot, FACS, immunocytochemistry and immunofluorescence procedures. By Western blot, this antibody detects an ~60 kDa band from human spinal cord homogenate, and a ~40 kda band from RBL2H3 cells, representing the different glycosylated forms of CB2.
PA1-744 antigen is a fusion protein containing the first 33 amino acid residues from human CB2.
Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P/Q type calcium channels.
CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cannabinoid receptor 2; cannabinoid receptor 2 (macrophage); CB-2; CB2; Cnr2; CX5; testis-dominant CNR2 isoform CB2
Gene Aliases: CB-2; CB2; CB2A; CB2B; CNR2; CX5
UniProt ID: (Human) P34972
Entrez Gene ID: (Human) 1269