PA1-746A detects cannabinoid receptor 2 (CB2) from human and rat tissues as well as transfected rat CB2.
PA1-746A has been successfully used in WB, immunocytochemistry, immunohistochemistry (paraffin) and FACS procedures. Immunocytochemical staining of CB2 into AtT20 cells transfected with the rat CB2 gene with PA1-746 yields a pattern consistent with plasma membrane staining.
PA1-746A antigen is a fusion protein containing the first 32 amino acid residues from rat CB2.
Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P/Q type calcium channels.
CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cannabinoid receptor 2; cannabinoid receptor 2 (macrophage); CB-2; CB2; CB2 receptor; Cnr2; CX5; peripheral cannabinoid receptor; rCB2; testis-dominant CNR2 isoform CB2
Gene Aliases: CB-2; CB2; CB2A; CB2B; CB2C; CNR2; CNR2C; CX5