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CNTNAP1 Antibody (PA5-42737) in WB
Western blot was performed using Anti-CNTNAP1 Polyclonal Antibody (Product # PA5-42737) and a 160kDa band corresponding to CNTNAP1 was observed in all cell and tissue lysates tested except Mouse Skeletal Muscle, Rat Skeletal Muscle, Mouse Liver and Rat Liver [DOI: 10.1016/s0896-6273(00)81049-1]. Whole cell extracts (30 µg lysate) of SH-SY5Y (Lane 1), Mouse Brain (Lane 2), Mouse Cerebellum (Lane 3), Rat Cerebellum (Lane 4), Mouse Skeletal Muscle (Lane 5), Rat Skeletal Muscle (Lane 6), Mouse Liver (Lane 7) and Rat Liver (Lane 8) were electro... View More
Product Details
PA5-42737
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human CNTNAP1 (aa 72-121).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2608278
Product Specific Information
Peptide sequence: LQIDLMKKHR IRAVATQGSF NSWDWVTRYM LLYGDRVDSW TPFYQRGHNS
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%
Target Information
CNTNAP1 was initially identified as a 190-kDa protein associated with the contactin-PTPRZ1 complex. The 1, 384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein, ' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. The gene product was initially identified as a 190-kDa protein associated with the contactin-PTPRZ1 complex. The 1, 381-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein, ' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Caspr; caspr1; Contactin-associated protein 1; Neurexin IV; Neurexin-4; p190
Gene Aliases: CASPR; CNTNAP; CNTNAP1; NRXN4; P190
UniProt ID: (Human) P78357
Entrez Gene ID: (Human) 8506
protein localization to paranode region of axon
cytoskeleton organization
cell adhesion
signal transduction
positive regulation of signal transduction
neuronal action potential propagation
paranodal junction assembly
neuron projection morphogenesis
neuromuscular process controlling posture
neuromuscular process controlling balance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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