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Invitrogen
COG2 Polyclonal Antibody
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FIGURE: 1 / 3
COG2 Antibody (PA5-109567) in IHC (P)
Immunohistochemistry analysis of COG2 in paraffin-embedded mouse kidney. Samples were incubated with COG2 Polyclonal antibody (Product # PA5-109567) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-109567
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human COG2 (NP_031383.1).
Conjugate
Form
Liquid
Concentration
1.1 mg/mL
Amount
110 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MEKSRMNLPK GPDTLCFDKD EFMKEDFDVD HFVSDCRKRV QLEELRDDLE LYYKLLKTAM VELINKDYAD FVNLSTNLVG MDKALNQLSV PLGQLREEVL SLRSSVSEGI RAVDERMSKQ EDIRKKKMCV LRLIQVIRSV EKIEKILNSQ SSKETSALEA SSPLLTGQIL ERIATEFNQL QFHAVQSKGM PLLDKVRPRI AGITAMLQQS LEGLLLEGLQ TSDVDIIRHC LRTYATIDKT RDAEALVGQV LVKPYIDEVI IEQFVESHPN GLQVMYNKLL
Target Information
The structure and function of the Golgi apparatus is controlled by a number of multi-protein complexes that are involved in glycosylation reactions and vesicular transport. The conserved oligomeric Golgi (COG) complex consists of three subcomplexes, termed LDLC, SEC34 and GTT (Golgi transport complex), all of which contain proteins necessary for proper Golgi operation. COG2 (conserved oligomeric Golgi complex subunit 2), also known as LDLC, is a 730 amino acid component of the COG complex. Localized to the cytoplasmic side of the Golgi apparatus, COG2 is required for proper Golgi morphology and function, specifically playing a role in Golgi ribbon formation and vesicular transport. Abnormal COG2 function may cause cell death, suggesting that COG2 is an important factor in cell viability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brefeldin A-sensitive, peripheral Golgi protein; COG 2; COG complex subunit 2; Component of oligomeric Golgi complex 2; conserved oligomeric Golgi complex protein 2; Conserved oligomeric Golgi complex subunit 2; low density lipoprotein receptor defect C complementing; Low density lipoprotein receptor defect C-complementing protein; Transcript ch4822; unnamed protein product
Gene Aliases: 1190002B08Rik; 2700012E02Rik; C86089; CDG2Q; COG2; LDLC
UniProt ID: (Human) Q14746, (Mouse) Q921L5
Entrez Gene ID: (Human) 22796, (Mouse) 76332, (Rat) 690961
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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