Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Peptide sequence: PGEPGYMGLP GIQGKKGDKG NQGEKGIQGQ KGENGRQGIP GQQGIQGHHG
Sequence homology: Dog: 93%; Horse: 100%; Human: 100%; Pig: 100%
COL17A1 is the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein, and a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. COL17A1 is a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Moreover, COL17A1 is localized to tissues containing type I collagen so, like other members of this collagen family, it may serve to maintain the integrity of the extracellular matrix. Diseases associated with COL17A1 dysfunction include epithelial recurrent erosion dystrophy and epidermolysis bullosa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alpha 1 chain-like collagen; Collagen alpha-1(XXI) chain; collagen, type XXI, alpha 1
Gene Aliases: COL1AL; COL21A1; COLA1L; FP633
UniProt ID: (Human) Q96P44
Entrez Gene ID: (Human) 81578
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