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Invitrogen
COL6A1 Polyclonal Antibody
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FIGURE: 1 / 9
COL6A1 Antibody (PA5-29068) in ICC/IF
Immunofluorescence analysis of COL6A1 was performed using 70% confluent log phase IMR-90 and SK-O-V3 cells. The cells were fixed with 4% paraformaldehyde for 5 minutes, permeabilized with 0.1% Triton™ X-100 for 5 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with COL6A1 Polyclonal Antibody (Product # PA5-29068) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (... View More
Product Details
PA5-29068
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human COL6A1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, U87-MG.
Predicted reactivity: Mouse (85%), Bovine (87%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The extensive family of COL gene products (collagens) is composed of several chain types, including fibril-forming interstitial collagens (typesI, II, III and V) and basement membrane collagens (type IV), each type containing multiple isoforms. Collagens are fibrous, extracellular matrix proteins with high tensile strength and are the major components of connective tissue, such as tendons and cartilage. All collagens contain a triple helix domain and frequently show lateral self-association in order to form complex connective tissues. Several collagens also play a role in cell adhesion, important for maintaining normal tissue architecture and function.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha 1 (VI) chain (61 AA); Collagen alpha-1(VI) chain; collagen VI, alpha-1 polypeptide; collagen, type VI, alpha 1; epididymis secretory sperm binding protein; procollagen, type VI, alpha 1; unnamed protein product
Gene Aliases: AI747156; BTHLM1; BTHLM1A; Col6a-1; COL6A1; OPLL; RGD1565398; UCHMD1; UCHMD1A
UniProt ID: (Human) P12109, (Mouse) Q04857
Entrez Gene ID: (Human) 1291, (Mouse) 12833, (Rat) 294337
response to reactive oxygen species
cell morphogenesis
ossification
osteoblast differentiation
hair follicle development
reduction of food intake in response to dietary excess
muscle system process
respiratory system process
glycolytic process
tricarboxylic acid cycle
2-oxoglutarate metabolic process
energy reserve metabolic process
autophagy
apoptotic process
inflammatory response
mitochondrion organization
cell adhesion
single fertilization
peripheral nervous system development
heart development
muscle organ development
skeletal muscle tissue development
circadian rhythm
insulin receptor signaling pathway
regulation of cell size
response to xenobiotic stimulus
response to UV
response to wounding
response to mechanical stimulus
response to toxic substance
anatomical structure morphogenesis
tissue development
gene expression
muscle cell apoptotic process
response to activity
response to muscle activity
transmission of nerve impulse
myelination in peripheral nervous system
cell differentiation
collagen fibril organization
apoptotic nuclear changes
bone mineralization
lung development
response to lipopolysaccharide
collagen metabolic process
response to lipid
endodermal cell differentiation
limb joint morphogenesis
response to decreased oxygen levels
skeletal muscle tissue regeneration
protein kinase B signaling
skin development
insulin-like growth factor receptor signaling pathway
response to pain
lung alveolus development
skeletal muscle tissue growth
skeletal muscle fiber development
tissue remodeling
homeostasis of number of cells
neurological system process
sensory perception of mechanical stimulus
cartilage development
protein tetramerization
neuron apoptotic process
mitochondrial depolarization
muscle cell development
uterus development
canonical Wnt signaling pathway
bone development
lung morphogenesis
lung epithelial cell differentiation
skeletal muscle organ development
adipose tissue development
muscle structure development
fat cell proliferation
caveola assembly
cellular response to amino acid stimulus
basement membrane organization
multicellular organismal locomotion
reactive oxygen species metabolic process
extracellular matrix assembly
energy homeostasis
skeletal muscle fiber differentiation
response to peptide
regulation of collagen fibril organization
response to polyamine macromolecule
response to bleomycin
mitochondrial transmembrane transport
protein heterotrimerization
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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