This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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Protein Aliases: CL-K1; Collectin 11; Collectin K1; Collectin kidney protein 1; collectin sub-family member 11; Collectin-11; Collectin11
Gene Aliases: 1010001H16Rik; 3MC2; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb; CLK1; COLEC11; UNQ596/PRO1182; wu:fb82e09; zgc:103572