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Recommended positive controls: A549, HeLa, HepG2, HCT116.
Predicted reactivity: Mouse (88%), Rat (89%), Pig (92%), Chicken (80%), Bovine (93%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The COMMD family represents a group of evolutionary conserved proteins that share a common COMM domain at their extreme C-terminus, which provides an interface for protein-protein interactions. COMMD10 (COMM domain containing 10), also known as PTD002 or HSPC305, is a 202 amino acid protein that belongs to the COMMD family and contains one COMM domain. The gene encoding COMMD10 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: COMM domain-containing protein 10; Down-regulated in W/WV mouse stomach 2; mDRWMS2
Gene Aliases: 2310003A05Rik; AU019438; COMMD10; DRWMS2; HSPC305; PTD002
UniProt ID: (Human) Q9Y6G5, (Mouse) Q8JZY2
Entrez Gene ID: (Human) 51397, (Mouse) 69456
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