Search
Invitrogen
COMT Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 3
COMT Antibody (PA5-18554) in IHC (P)
Immunohistochemistry analysis of COMT in human small intestine. Samples were incubated with COMT polyclonal antibody (Product # PA5-18554) using a dilution of 3.75 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Product Details
PA5-18554
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (QDIIPQLKKKYDVD) corresponding to the internal amino acids of COMT (aa 170-184).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Catechol O-methyltransferase; COMT; epididymis secretory sperm binding protein Li 98n; OTTHUMP00000197749; OTTHUMP00000197750; testicular tissue protein Li 42; unnamed protein product
Gene Aliases: COMT; HEL-S-98n
UniProt ID: (Human) P21964
Entrez Gene ID: (Human) 1312
behavioral fear response
response to hypoxia
kidney development
synaptic transmission, dopaminergic
startle response
response to amphetamine
renin secretion into blood stream
glycogen metabolic process
catecholamine metabolic process
lipid metabolic process
prostaglandin metabolic process
response to stress
response to oxidative stress
learning or memory
learning
memory
regulation of blood pressure
visual learning
response to temperature stimulus
response to xenobiotic stimulus
response to wounding
response to toxic substance
gene expression
dopamine secretion
cellular response to phosphate starvation
cerebellar cortex morphogenesis
response to food
methylation
developmental process
glomerulus development
cholesterol efflux
multicellular organismal response to stress
response to cytokine
multicellular organism growth
exploration behavior
renal sodium excretion
norepinephrine metabolic process
dopamine metabolic process
dopamine catabolic process
catecholamine catabolic process
fear response
habituation
norepinephrine secretion
cognition
detection of temperature stimulus involved in sensory perception of pain
response to corticosterone
artery development
cellular response to cocaine
mastication
renal albumin absorption
renal filtration
response to salt
response to dopamine
response to angiotensin
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support