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Invitrogen
COPG Polyclonal Antibody
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Product Details
PA5-58146
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human COPG. Recombinant protein control fragment (Product #RP-96463).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VKQPEKVAAT RQEIFQEQLA AVPEFRGLGP LFKSSPEPVA LTESETEYVI RCTKHTFTNH MVFQFDCTNT LNDQTLENVT VQMEPTE
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
Target Information
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: coat protein gamma-cop; coatomer protein complex, subunit gamma 1; coatomer subunit gamma; Coatomer subunit gamma-1; Gamma-1-coat protein; Gamma-1-COP; gamma-coat protein; gamma-COP
Gene Aliases: AU019265; BC056168; COPG; COPG1; D6Ertd71e; D6Wsu16e
UniProt ID: (Human) Q9Y678, (Mouse) Q9QZE5, (Rat) Q4AEF8
Entrez Gene ID: (Human) 22820, (Mouse) 54161, (Rat) 297428
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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