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Proteintech
COPS2/TRIP15 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
10969-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Bovine,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
COPS2/TRIP15 Fusion Protein Ag1415 (1-443 aa encoded by BC012629)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.49 mg/mL
Amount
73.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Product # 10969-2-AP is a rabbit polyclonal antibody raised against the full-length of human COPS2. The MW of this protein is 52 kDa, and this antibody specifically recognizes the 52 kDa protein.
Immunogen sequence: MSDMEDDFM CDDEEDYDLE YSEDSNSEPN VDLENQYYNS KALKEDDPKA ALSSFQKVLE LEGEKGEWGF KALKQMIKIN FKLTNFPEMM NRYKQLLTYI RSAVTRNYSE KSINSILDYI STSKQMDLLQ EFYETTLEAL KDAKNDRLWF KTNTKLGKLY LEREEYGKLQ KILRQLHQSC QTDDGEDDLK KGTQLLEIYA LEIQMYTAQK NNKKLKALYE QSLHIKSAIP HPLIMGVIRE CGGKMHLREG EFEKAHTDFF EAFKNYDESG SPRRTTCLKY LVLANMLMKS GINPFDSQEA KPYKNDPEIL AMTNLVSAYQ NNDITEFEKI LKTNHSNIMD DPFIREHIEE LLRNIRTQVL IKLIKPYTRI HIPFISKELN IDVADVESLL VQCILDNTIH GRIDQVNQLL ELDHQKRGGA RYTALDKWTN QLNSLNQAVV SKLA (1-443 aa encoded by BC012629)
Target Information
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alien homolog; alien-like; COP9; COP9 (constitutive photomorphogenic) homolog, subunit 2; COP9 constitutive photomorphogenic homolog subunit 2; corepressor for nuclear hormone receptors; JAB1-containing signalosome subunit 2; signalosome subunit 2; similar to human Trip15; subunit of the signalosome complex; thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15; TRIP15; unnamed protein product
Gene Aliases: ALIEN; CSN2; SGN2; TRIP-15; TRIP15
UniProt ID: (Human) P61201, (Mouse) P61202
Entrez Gene ID: (Human) 9318, (Mouse) 12848
negative regulation of transcription from RNA polymerase II promoter
protein deneddylation
transcription from RNA polymerase II promoter
protein phosphorylation
signal transduction
neuron differentiation
protein neddylation
regulation of protein neddylation
inner cell mass cell proliferation
cell proliferation
skeletal muscle cell differentiation
negative regulation of transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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