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COPS2/TRIP15 Polyclonal Antibody

COPS2/TRIP15 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 10

COPS2/TRIP15 Antibody (10969-2-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 10969-2-AP (COPS2/TRIP15 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

COPS2/TRIP15 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

COPS2/TRIP15 Antibody in Western Blot (WB)

COPS2/TRIP15 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10969-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Bovine, Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

COPS2/TRIP15 Fusion Protein Ag1415 (1-443 aa encoded by BC012629)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.49 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Product # 10969-2-AP is a rabbit polyclonal antibody raised against the full-length of human COPS2. The MW of this protein is 52 kDa, and this antibody specifically recognizes the 52 kDa protein.

Immunogen sequence: MSDMEDDFM CDDEEDYDLE YSEDSNSEPN VDLENQYYNS KALKEDDPKA ALSSFQKVLE LEGEKGEWGF KALKQMIKIN FKLTNFPEMM NRYKQLLTYI RSAVTRNYSE KSINSILDYI STSKQMDLLQ EFYETTLEAL KDAKNDRLWF KTNTKLGKLY LEREEYGKLQ KILRQLHQSC QTDDGEDDLK KGTQLLEIYA LEIQMYTAQK NNKKLKALYE QSLHIKSAIP HPLIMGVIRE CGGKMHLREG EFEKAHTDFF EAFKNYDESG SPRRTTCLKY LVLANMLMKS GINPFDSQEA KPYKNDPEIL AMTNLVSAYQ NNDITEFEKI LKTNHSNIMD DPFIREHIEE LLRNIRTQVL IKLIKPYTRI HIPFISKELN IDVADVESLL VQCILDNTIH GRIDQVNQLL ELDHQKRGGA RYTALDKWTN QLNSLNQAVV SKLA (1-443 aa encoded by BC012629)

Target Information

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.

iScience

Hsu YH,Pintacuda G,Liu R,Nacu E,Kim A,Tsafou K,Petrossian N,Crotty W,Suh JM,Riseman J,Martin JM,Biagini JC,Mena D,Ching JKT,Malolepsza E,Li T,Singh T,Ge T,Egri SB,Tanenbaum B,Stanclift CR,Apffel AM,Carr SA,Schenone M,Jaffe J,Fornelos N,Huang H,Eggan KC,Lage K

Fri May 19 00:00:00 EDT 2023

miR-27a-3p relieves heat stress-induced mitochondrial damage and aberrant milk protein synthesis through MEK/ERK pathway in BMECs.

Cell stress & chaperones

Wang Y,Wu J,Xia SW,Zhao F,Ding Q,Ye XM,Zhong JF,Chen KL,Wang HL

Mon May 01 00:00:00 EDT 2023

COP9 Signalosome Subunit 3 Restricts Neuroinflammatory Responses During Cerebral Ischemia/Reperfusion Injury Through Stabilizing Suppressor of Cytokine Signaling 3 Protein.

Neuropsychiatric disease and treatment

Liang E,Li X,Fu W,Zhao C,Yang B,Yang Z

Fri Apr 22 00:00:00 EDT 2022

IP₆-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion.

Nature communications

Lin H,Yan Y,Luo Y,So WY,Wei X,Zhang X,Yang X,Zhang J,Su Y,Yang X,Zhang B,Zhang K,Jiang N,Chow BKC,Han W,Wang F,Rao F

Wed Apr 28 00:00:00 EDT 2021

Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome.

Proceedings of the National Academy of Sciences of the United States of America

Lin H,Zhang X,Liu L,Fu Q,Zang C,Ding Y,Su Y,Xu Z,He S,Yang X,Wei X,Mao H,Cui Y,Wei Y,Zhou C,Du L,Huang N,Zheng N,Wang T,Rao F

Tue Feb 25 00:00:00 EST 2020

Kisspeptin-10 Induces β-Casein Synthesis via GPR54 and Its Downstream Signaling Pathways in Bovine Mammary Epithelial Cells.

International journal of molecular sciences

Sun J,Liu J,Huang B,Kan X,Chen G,Wang W,Fu S

Tue Dec 05 00:00:00 EST 2017

Kisspeptin-10 Induces β-Casein Synthesis via GPR54 and Its Downstream Signaling Pathways in Bovine Mammary Epithelial Cells.

International journal of molecular sciences

Sun J,Liu J,Huang B,Kan X,Chen G,Wang W,Fu S

Tue Dec 05 00:00:00 EST 2017

RMP promotes epithelial-mesenchymal transition through NF-κB/CSN2/Snail pathway in hepatocellular carcinoma.

Oncotarget

Zhou W,Wang Q,Xu Y,Jiang J,Guo J,Yu H,Wei W

Tue Jun 20 00:00:00 EDT 2017

Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function.

Proceedings of the National Academy of Sciences of the United States of America

Scherer PC,Ding Y,Liu Z,Xu J,Mao H,Barrow JC,Wei N,Zheng N,Snyder SH,Rao F

Tue Mar 29 00:00:00 EDT 2016

Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function.

Proceedings of the National Academy of Sciences of the United States of America

Scherer PC,Ding Y,Liu Z,Xu J,Mao H,Barrow JC,Wei N,Zheng N,Snyder SH,Rao F

Tue Mar 29 00:00:00 EDT 2016

Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death.

Proceedings of the National Academy of Sciences of the United States of America

Rao F,Xu J,Khan AB,Gadalla MM,Cha JY,Xu R,Tyagi R,Dang Y,Chakraborty A,Snyder SH

Tue Nov 11 00:00:00 EST 2014

Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death.

Proceedings of the National Academy of Sciences of the United States of America

Rao F,Xu J,Khan AB,Gadalla MM,Cha JY,Xu R,Tyagi R,Dang Y,Chakraborty A,Snyder SH

Tue Nov 11 00:00:00 EST 2014

Bioinformatics

Protein Aliases: Alien homolog; alien-like; COP9; COP9 constitutive photomorphogenic homolog subunit 2; COP9 signalosome complex subunit 2; JAB1-containing signalosome subunit 2; SGN2; signalosome subunit 2; thyroid receptor interacting protein 15; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15

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Gene Aliases: AI315723; ALIEN; C85265; COPS2; CSN2; SGN2; TRIP-15; TRIP15

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UniProt ID: (Human) P61201, (Mouse) P61202

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Entrez Gene ID: (Human) 9318, (Mouse) 12848

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Function(s)

transcription corepressor activity signal transducer activity protein binding

Process(es)

negative regulation of transcription from RNA polymerase II promoter nucleotide-excision repair, DNA damage recognition transcription-coupled nucleotide-excision repair transcription from RNA polymerase II promoter signal transduction cell proliferation cullin deneddylation neuron differentiation skeletal muscle cell differentiation negative regulation of nucleic acid-templated transcription negative regulation of transcription, DNA-templated

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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COPS2/TRIP15 Polyclonal Antibody

COPS2/TRIP15 Antibody (10969-2-AP) in ICC/IF

Product Details

10969-2-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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