Proteintech

COQ4 Polyclonal Antibody

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COQ4 Antibody (16654-1-AP) in WB

Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with 16654-1-AP ( COQ4 Antibody) at dilution of 1:700 incubated at room temperature for 1.5 hours.

COQ4 Antibody in Immunoprecipitation (IP)

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Product Details

16654-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:2,000

View 7 publications 7 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

COQ4 Fusion Protein Ag10089 (1-265 aa encoded by BC011895)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MATLLRPVL RRLCGLPGLQ RPAAEMPLRA RSDGAGPLYS HHLPTSPLQK ALLAAGSAAM ALYNPYRHDM VAVLGETTGH RTLKVLRDQM RRDPEGAQIL QERPRISTST LDLGKLQSLP EGSLGREYLR FLDVNRVSPD TRAPTRFVDD EELAYVIQRY REVHDMLHTL LGMPTNILGE IVVKWFEAVQ TGLPMCILGA FFGPIRLGAQ SLQVLVSELI PWAVQNGRRA PCVLNLYYER RWEQSLRALR EELGITAPPM HVQGLA (1-265 aa encoded by B C011895)

Target Information

Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The Q-junction and the inflammatory response are critical pathological and therapeutic factors in CoQ deficiency.

Redox biology

González-García P,Díaz-Casado ME,Hidalgo-Gutiérrez A,Jiménez-Sánchez L,Bakkali M,Barriocanal-Casado E,Escames G,Chiozzi RZ,Völlmy F,Zaal EA,Berkers CR,Heck AJR,López LC

Thu Sep 01 00:00:00 UTC 2022

Human COQ4 deficiency: delineating the clinical, metabolic and neuroimaging phenotypes.

Journal of medical genetics

Laugwitz L,Seibt A,Herebian D,Peralta S,Kienzle I,Buchert R,Falb R,Gauck D,Müller A,Grimmel M,Beck-Woedel S,Kern J,Daliri K,Katibeh P,Danhauser K,Leiz S,Alesi V,Baertling F,Vasco G,Steinfeld R,Wagner M,Caglayan AO,Gumus H,Burmeister M,Mayatepek E,Martinelli D,Tamhankar PM,Tamhankar V,Joset P,Steindl K,Rauch A,Bonnen PE,Froukh T,Groeschel S,Krägeloh-Mann I,Haack TB,Distelmaier F

Thu Sep 01 00:00:00 UTC 2022

Characterization of human mitochondrial PDSS and COQ proteins and their roles in maintaining coenzyme Q₁₀ levels and each other's stability.

Biochimica et biophysica acta. Bioenergetics

Yen HC,Yeh WY,Lee SH,Feng YH,Yang SL

Wed Jul 01 00:00:00 UTC 2020

Resveratrol Regulates the Expression of Genes Involved in CoQ Synthesis in Liver in Mice Fed with High Fat Diet.

Antioxidants (Basel, Switzerland)

Meza-Torres C,Hernández-Camacho JD,Cortés-Rodríguez AB,Fang L,Bui Thanh T,Rodríguez-Bies E,Navas P,López-Lluch G

Fri May 15 00:00:00 UTC 2020

β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 mice.

EMBO molecular medicine

Hidalgo-Gutiérrez A,Barriocanal-Casado E,Bakkali M,Díaz-Casado ME,Sánchez-Maldonado L,Romero M,Sayed RK,Prehn C,Escames G,Duarte J,Acuña-Castroviejo D,López LC

Tue Jan 01 00:00:00 UTC 2019

β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 mice.

EMBO molecular medicine

Hidalgo-Gutiérrez A,Barriocanal-Casado E,Bakkali M,Díaz-Casado ME,Sánchez-Maldonado L,Romero M,Sayed RK,Prehn C,Escames G,Duarte J,Acuña-Castroviejo D,López LC

Tue Jan 01 00:00:00 UTC 2019

Detection of 6-demethoxyubiquinone in CoQ₁₀ deficiency disorders: Insights into enzyme interactions and identification of potential therapeutics.

Molecular genetics and metabolism

Herebian D,Seibt A,Smits SHJ,Bünning G,Freyer C,Prokisch H,Karall D,Wredenberg A,Wedell A,López LC,Mayatepek E,Distelmaier F

Sat Jul 01 00:00:00 UTC 2017

Detection of 6-demethoxyubiquinone in CoQ₁₀ deficiency disorders: Insights into enzyme interactions and identification of potential therapeutics.

Molecular genetics and metabolism

Herebian D,Seibt A,Smits SHJ,Bünning G,Freyer C,Prokisch H,Karall D,Wredenberg A,Wedell A,López LC,Mayatepek E,Distelmaier F

Sat Jul 01 00:00:00 UTC 2017

4-Hydroxybenzoic acid restores CoQ₁₀ biosynthesis in human COQ2 deficiency.

Annals of clinical and translational neurology

Herebian D,Seibt A,Smits SHJ,Rodenburg RJ,Mayatepek E,Distelmaier F

Fri Dec 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: Coenzyme Q biosynthesis protein 4 homolog; coenzyme Q biosynthesis protein 4 homolog {ECO:0000255|HAMAP-Rule:MF_03111}; coenzyme Q4 homolog; EST-MNCb4625; Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; ubiquinone biosynthesis protein COQ4 homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111}

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Gene Aliases: A330041N06; CGI-92; COQ10D7; COQ4; D2Ertd97e

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UniProt ID: (Human) Q9Y3A0, (Mouse) Q8BGB8, (Rat) Q4FZU1

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Entrez Gene ID: (Human) 51117, (Mouse) 227683, (Rat) 366013

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Function(s)

molecular_function

Process(es)

ubiquinone biosynthetic process biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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COQ4 Polyclonal Antibody

COQ4 Antibody (16654-1-AP) in WB

Product Details

16654-1-AP

Western Blot (WB)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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