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This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.
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Protein Aliases: coactosin-like 1; coactosin-like F-actin binding protein 1; Coactosin-like protein; FLJ43657; MGC19733
Gene Aliases: 1810074P22Rik; 2010004C08Rik; CLP; COTL1
UniProt ID: (Human) Q14019, (Mouse) Q9CQI6
Entrez Gene ID: (Human) 23406, (Mouse) 72042
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