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Peptide sequence: MATKIDKEAC RAAYNLVRDD GSAVIWVTFK YDGSTIVPGE QGAEYQHFIQ
Sequence homology: Cow: 85%; Guinea Pig: 85%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 83%
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: coactosin-like 1; coactosin-like F-actin binding protein 1; Coactosin-like protein; FLJ43657; MGC19733
Gene Aliases: CLP; COTL1
UniProt ID: (Human) Q14019
Entrez Gene ID: (Human) 23406
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