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Product Details
10611-2-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:200-1:1,000 | View 3 publications 3 publications |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
COX10 Fusion Protein Ag0930 (1-300 aa encoded by BC006394) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.33 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: MAASPHTLS SRLLTGCVGG SVWYLERRTI QDSPHKFLHL LRNVNKQWIT FQHFSFLKRM YVTQLNRSHN QQVRPKPEPV ASPFLEKTSS GQAKAEIYEM RPLSPPSLSL SRKPNEKELI ELEPDSVIED SIDVGKETKE EKRWKEMKLQ VYDLPGILAQ LSKIKLTALV VSTTAAGFAL APGPFDWPCF LLTSVGTGLA SCAANSINQF FEVPFDSNMN RTKNRPLVRG QISPLLAVSF ATCCAVPGVA ILTLGVNPLT GALGLFNIFL YTCCYTPLKR ISIANTWVGA VVGAIPPVMG W (1-300 aa encoded by BC006394)
Target Information
Defects in COX10 are a cause of mitochondrial complex IV deficiency (MT-C4D); also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase; cytochrome c oxidase assembly homolog 10; cytochrome c oxidase assembly protein; cytochrome c oxidase subunit X; heme A: farnesyltransferase; Heme O synthase; Protoheme IX farnesyltransferase, mitochondrial; similar to COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase
Gene Aliases: 2410004F01Rik; AU042636; COX10
UniProt ID: (Human) Q12887, (Mouse) Q8CFY5
Entrez Gene ID: (Human) 1352, (Mouse) 70383, (Rat) 691853
Molecular Function:
acyltransferase
mitochondrial fission
mitochondrial electron transport, cytochrome c to oxygen
heme biosynthetic process
heme a biosynthetic process
respiratory chain complex IV assembly
aerobic respiration
cellular respiration
heme O biosynthetic process
hydrogen ion transmembrane transport
mitochondrion organization
cytochrome complex assembly
protein farnesylation
cytochrome-c oxidase activity
farnesyltranstransferase activity
protoheme IX farnesyltransferase activity
prenyltransferase activity
protein geranylgeranyltransferase activity
protein prenyltransferase activity
4-hydroxybenzoate octaprenyltransferase activity
transferase activity
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity
cadaverine aminopropyltransferase activity
agmatine aminopropyltransferase activity
1,4-dihydroxy-2-naphthoate octaprenyltransferase activity
trans-pentaprenyltranstransferase activity
ATP dimethylallyltransferase activity
ADP dimethylallyltransferase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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