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Immunogen sequence: MQRLLFPPL RALKGRQYLP LLAPRAAPRA QCDCIRRPLR PGQYSTISEV ALQSGRGTVS LPSKAAERVV GRWLLVCSGT VAGAVILGGV TRLTESGLSM VDWHLIKEMK PPTSQEEWEA EFQRYQQFPE FKILNHDMTL TEFKFIWYME YSHRMWGRLV GLVYILPAAY FWRKGWLSRG MKGRVLALCG LVCFQGLLGW YMVKSGLEEK SDSHDIPRVS QYRLAAHLGS ALVLYCASLW TSLSLLLPPH KLPETHQLLQ LRRFAHGTAG LVFLTALSGA FVAGLDAGLV YNSFPKMGES WIPEDLFTFS PILRNVFENP TMVQFDHRIL GITSVTAITV LYFLSRRIPL PRRTKMAAVT LLALAYTQVG LGISTLLMYV PTPLAATHQS GSLALLTGAL WLMNELRRVP K (1-410 aa encoded by BC002382)
The cytochrome c oxidase (COX) family of proteins function as the final electron donor in the respiratory chain to drive a proton gradient across the inner mitochondrial membrane, ultimately resulting in the production of water. The mammalian COX apoenzyme is a dimer, with each monomer consisting of 13 subunits, some of which are mitochondrial and some of which are nuclear. COX15 (cytochrome c oxidase assembly protein COX15 homolog) is a 410 amino acid multi-pass mitochondrial membrane protein belonging to the COX15/ctaA family. Existing as two alternatively spliced isoforms, COX15 is predominantly expressed in tissues containing high rates of oxidative phosphorylation including brain, heart and muscle. COX15 defects are the cause of a neurodegenerative disorder known as Leigh syndrome and cytochrome c oxidase deficiency (COX deficiency).
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Protein Aliases: COX15 cytochrome c oxidase assembly homolog; COX15 homolog, cytochrome c oxidase assembly protein; cytochrome c oxidase assembly homolog 15; Cytochrome c oxidase assembly protein COX15 homolog; cytochrome c oxidase subunit 15
Gene Aliases: 2900026G05Rik; CEMCOX2; COX15
Molecular Function: chaperone