PA1-1100 detects recombinant mouse and rat CPEB (cytoplasmic polyadenylation element binding protein).
PA1-1100 has been successfully used in Western blot, ICC/IF and IHC-P procedures. By Western blot, this antibody detects ~62 and kDa protein representing recombinant mouse CPEB.
The PA1-1100 immunogen is a synthetic peptide corresponding to residues C H(545) S M E G L R H H S P L M R N Q K N(562) of human CPEB. This sequence is completely conserved in mouse. The PA1-1100 immunizing peptide (Cat. # PEP-171) is available for use in neutralization and control experiments.
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the nuclear membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the nuclear membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CEBP; CPE-binding protein 1; CPE-BP1; CPEB; CPEB-1; Cytoplasmic polyadenylation element-binding protein 1; FLJ13203; h-CEBP; mCPEB-1; MGC34136; MGC60106
Gene Aliases: AU024112; CPE-BP1; CPEB; CPEB-1; CPEB1; h-CPEB; hCPEB-1; mCPEB
Molecular Function: mRNA polyadenylation factor