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CPLA2 Polyclonal Antibody

View all (17) PLA2G4A antibodies

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CPLA2 Polyclonal Antibody

Product Details

BS-7560R

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human CPLA2, amino acids 501-600.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: calcium-dependent phospholipid-binding protein; cPLA2; cytosolic group IVA; Cytosolic phospholipase A2; group IVA; lysophospholipase; MGC126350; phosphatidylcholine 2-acylhydrolase; phospholipase A2; phospholipase A2 cytosolic; Phospholipase A2 group IVA; phospholipase A2, group IVA (cytosolic, calcium-dependent); unnamed protein product

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Gene Aliases: CPLA2; cPLA2-alpha; cPLA2alpha; GURDP; Pla2c; PLA2G4; PLA2G4A

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UniProt ID: (Human) P47712, (Mouse) P47713

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Entrez Gene ID: (Human) 5321, (Mouse) 18783, (Rat) 24653

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Function(s)
phospholipase activity lysophospholipase activity phospholipase A2 activity calcium ion binding calcium-dependent phospholipid binding lipid binding O-acyltransferase activity phosphatidylinositol-5-phosphate binding hydrolase activity phosphatidylinositol-3-phosphate binding metal ion binding calcium-dependent phospholipase A2 activity calcium-independent phospholipase A2 activity carboxylic ester hydrolase activity phosphatidylinositol-4-phosphate binding ceramide 1-phosphate binding histone acetyltransferase binding phospholipase
Process(es)
prostaglandin biosynthetic process positive regulation of T-helper 1 type immune response glycerol metabolic process lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process monoacylglycerol biosynthetic process glycerophospholipid metabolic process platelet activating factor biosynthetic process icosanoid metabolic process prostaglandin metabolic process phospholipid catabolic process positive regulation of platelet activation lipid catabolic process arachidonic acid metabolic process leukotriene biosynthetic process positive regulation of prostaglandin secretion phosphatidylglycerol catabolic process phosphatidylcholine catabolic process phosphatidylcholine acyl-chain remodeling regulation of cell proliferation positive regulation of macrophage activation icosanoid biosynthetic process glycerophospholipid catabolic process arachidonic acid secretion establishment of localization in cell cellular response to antibiotic ovulation from ovarian follicle luteolysis aging positive regulation of cell proliferation response to heat response to hormone response to organic substance response to lithium ion response to organonitrogen compound positive regulation of bone mineralization positive regulation of vesicle fusion positive regulation of prostaglandin biosynthetic process positive regulation of fever generation response to lipopolysaccharide response to vitamin D response to hydrogen peroxide positive regulation of apoptotic process surfactant homeostasis decidualization positive regulation of inflammatory response response to glucocorticoid response to calcium ion response to methylmercury
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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