Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: TSLGRPEEEE DELAHRCSSF MAPPVTDLGE LRRRPGDMKT KMELLILETQ AQVCQALAQV DGGANFSVDR WERKEGGGGI SCVLQDGCVF EKAGVSISVV HGNLSEEAAK QMRSRGKVLK TKDGKLPFCA MGVSSVIHPK NPHAPTIHFN YRYFEVEEAD GNKQWWFGGG CDLTPTYLNQ EDAVHFHRTL KEACDQHGPD LYPKFKKWCD DYFFIAHRGE RRGIGGIFFD DLDSPSKEEV FRFVQSCARA VVPSYIPLVK KHCDDSFTPQ EKLWQQLRRG RYVEFNLLYD RGTKFGLFTP GSRIESILMS LPLTARWEYM HSPSENSKEA EILEVLRHPR DWVR; Positive Samples: HeLa, A375, HepG2, A-549, Mouse liver, Rat liver; Cellular Location: Mitochondrion intermembrane space
The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: clone 560; coprogen oxidase; Coproporphyrinogen III oxidase, mitochondrial precursor (Coproporphyrinogenase) (Coprogen oxidase) (COX); coproporphyrinogen-III oxidase, mitochondrial; coproporphyrinogenase; COX; cpox {ECO:0000312|EMBL:AAI07665.1}; Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
Gene Aliases: cac; CPO; CPOX; CPX; HCP; nct
UniProt ID: (Human) P36551, (Rat) Q3B7D0, (Mouse) P36552
Entrez Gene ID: (Human) 1371, (Rat) 304024, (Mouse) 12892
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